Three repeat isoforms of tau inhibit assembly of four repeat tau filaments

Tauopathies are defined by assembly of the microtubule associated protein tau into filamentous tangles and classified by the predominant tau isoform within these aggregates. The major isoforms are determined by alternative mRNA splicing of exon 10 generating tau with three (3R) or four (4R) approxim...

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Veröffentlicht in:	PloS one 2010-05, Vol.5 (5), p.e10810-e10810
Hauptverfasser:	Adams, Stephanie J, DeTure, Michael A, McBride, Melinda, Dickson, Dennis W, Petrucelli, Leonard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adams, Michael Agglomeration Alternative splicing Amino acids Anticoagulants Assembly Biochemistry/Protein Chemistry Brain Chromatography Exons Filaments Heparin Humans Inserts Isoforms Kinetics Medicine mRNA Mutation Neurodegeneration Neurodegenerative diseases Neurological Disorders/Alzheimer Disease Neuroscience/Neurobiology of Disease and Regeneration Neurosciences Pathology Polymerization Protein Binding Protein Isoforms - chemistry Protein Isoforms - isolation & purification Protein Isoforms - metabolism Protein Isoforms - ultrastructure Protein Structure, Quaternary Proteins Ratios Recombinant Proteins - isolation & purification Repetitive Sequences, Amino Acid Restoration Tau protein tau Proteins - chemistry tau Proteins - isolation & purification tau Proteins - metabolism tau Proteins - ultrastructure Thiazoles - metabolism Transgenic animals
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