R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models

HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but have proved difficult to elicit. Although some current immunogens elicit antibodies that neutralize highly neutralization-sensitive (tier 1) H...

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Veröffentlicht in:	PloS one 2010-07, Vol.5 (7), p.e11689
Hauptverfasser:	Siddappa, Nagadenahalli B, Watkins, Jennifer D, Wassermann, Klemens J, Song, Ruijiang, Wang, Wendy, Kramer, Victor G, Lakhashe, Samir, Santosuosso, Michael, Poznansky, Mark C, Novembre, Francis J, Villinger, François, Else, James G, Montefiori, David C, Rasmussen, Robert A, Ruprecht, Ruth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS vaccines AIDS Vaccines - genetics AIDS Vaccines - immunology Animal behavior Animals Antibodies Antibodies, Neutralizing - immunology Binding sites CD4 antigen Disease Models, Animal Evolution Evolution, Molecular Genes, env - genetics HIV HIV-1 - genetics HIV-1 - immunology HIV-1 - pathogenicity Human immunodeficiency virus Human immunodeficiency virus 1 Infectious Diseases Infectious Diseases/HIV Infection and AIDS Lymphocytes Lymphocytes T Macaca mulatta Molecular modelling Molecular Sequence Data Monkeys & apes Mutagenesis, Site-Directed Mutation Neutralization Polymerase Chain Reaction Primates Ribonucleic acid RNA Sensitivity Simian/human immunodeficiency virus Strains (organisms) T cells Vaccine development Vaccines Virology Virology/Animal Models of Infection Virology/Immunodeficiency Viruses Virology/Vaccines Viruses
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