Liposome-coupled peptides induce long-lived memory CD8 T cells without CD4 T cells

CD8(+) T cells provide broad immunity to viruses, because they are able to recognize all types of viral proteins. Therefore, the development of vaccines capable of inducing long-lived memory CD8(+) T cells is desired to prevent diseases, especially those for which no vaccines currently exist. Howeve...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e15091-e15091
Hauptverfasser:	Taneichi, Maiko, Tanaka, Yuriko, Kakiuchi, Terutaka, Uchida, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Avian flu Biology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Cells, Cultured Coronaviridae Coronaviruses Cytokines Cytokines - immunology Cytokines - metabolism Cytotoxicity Cytotoxicity, Immunologic - immunology Drug dosages Enzyme-Linked Immunosorbent Assay Epitopes Epitopes, T-Lymphocyte - immunology HIV Human immunodeficiency virus Humoral immunity Immunity Immunization Immunologic Memory - immunology Immunological memory Immunology Infections Infectious diseases Influenza Liposomes Liposomes - immunology Lymphocytes Lymphocytes T Medicine Memory cells Mice Ovalbumin - immunology Peptide Fragments - immunology Peptides Peptides - immunology Proteins Safety research T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Transgenic animals Vaccines Viral diseases Viruses
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