Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis

Peripheral neuroblastic tumors (PNTs) share a common origin in the sympathetic nervous system, but manifest variable differentiation and growth potential. Malignant neuroblastoma (NB) and benign ganglioneuroma (GN) stand at opposite ends of the clinical spectrum. We hypothesize that a common PNT pro...

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Veröffentlicht in:	PloS one 2009-10, Vol.4 (10), p.e7491-e7491
Hauptverfasser:	Gershon, Timothy R, Shiraz, Ashton, Shirazi, Arash, Qin, Li-Xuan, Gerald, William L, Kenney, Anna M, Cheung, Nai-Kong
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Benign Biosynthesis Cancer Catecholamines - metabolism Cell Differentiation Cell Line, Tumor Cell proliferation Comparative analysis Developmental Biology/Developmental Molecular Mechanisms Developmental Biology/Neurodevelopment Differentiation Divergence Enteric nervous system Enteric Nervous System - pathology Enzymes Ganglia Ganglioneuroma - metabolism Ganglioneuroma - pathology Gene expression Gene Expression Regulation, Neoplastic Genes Genotype & phenotype Hedgehog protein Hedgehog Proteins - metabolism Humans Literature reviews Mice Myc protein Nervous system Neural crest Neural Crest - cytology Neuroblastoma Neuroblastoma - metabolism Neuroblastoma cells Neurological Disorders/Neuro-Oncology Neuropeptides Neuropeptides - chemistry Oncology/Neuro-Oncology Oncology/Pediatric Oncology Pathogenesis Pediatrics Physiological aspects Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-ret - biosynthesis Retinoic acid Rodents Signal Transduction Signaling Stem cells Sympathetic nervous system Transcription Transcription (Genetics) Transgenic animals Tumors
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