Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects

Although the potent anti-parkinsonian action of the atypical D₁-like receptor agonist SKF83959 has been attributed to the selective activation of phosphoinositol(PI)-linked D₁ receptor, whereas the mechanism underlying its potent neuroprotective effect is not fully understood. In the present study,...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13118
Hauptverfasser:	Chu, Hong-Yuan, Gu, Qinhua, Jin, Guo-Zhang, Hu, Guo-Yuan, Zhen, Xuechu
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology Activation Adrenergic receptors Analysis Animals Antagonists Antiparkinson agents Basal ganglia Brain research Brain slice preparation Central nervous system diseases Depolarization Dialysis Dopamine Excitability Hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Kinases Laboratories Membrane potential Membrane Potentials - drug effects Movement disorders Neurodegenerative diseases Neurological Disorders/Neuropharmacology Neurons Neurons - drug effects Neuroprotection Neuroprotective Agents - pharmacology Parkinson's disease Parkinsons disease Patch-Clamp Techniques Pharmacology Pharmacology/Drug Development Physiology Pyramidal cells Pyramidal Cells - drug effects Rats Receptor mechanisms Receptors Reduction Rodents Serotonin S2 receptors Trends
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