Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages

Amyloid beta (Aβ) accumulates in the ageing central nervous system and is associated with a number of age-related diseases, including age-related macular degeneration (AMD) in the eye. AMD is characterised by accumulation of extracellular deposits called drusen in which Aβ is a key constituent. Aβ a...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13127
Hauptverfasser:	Hoh Kam, Jaimie, Lenassi, Eva, Jeffery, Glen
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Age Age related diseases Aging Aging - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Blood Blood vessels Blotting, Western Central nervous system Cognitive ability Deposition Electron microscopy Eye Eye (anatomy) Humans Immunohistochemistry Macrophage Activation Macrophages Macrophages - cytology Macular degeneration Macular Degeneration - metabolism Metabolism Mice Neuroscience Ophthalmology Ophthalmology/Macular Disorders Ophthalmology/Retinal Disorders Perfusion Photoreceptors Retina Retina - cytology Retina - metabolism Rodents Scanning electron microscopy Segments Studies Up-Regulation Visual perception β-Amyloid
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