Salmonella Induced IL-23 and IL-1β Allow for IL-12 Production by Monocytes and Mφ1 through Induction of IFN-γ in CD56+ NK/NK-Like T Cells

Background The type-1 cytokine pathway plays a pivotal role in immunity against intracellular bacterial pathogens such as Salmonellae and Mycobacteria. Bacterial stimulation of pattern recognition receptors on monocytes, macrophages and dendritic cells initiates this pathway, and results in the prod...

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Veröffentlicht in:	PloS one 2009-12, Vol.4 (12), p.e8396
Hauptverfasser:	van de Wetering, Diederik, de Paus, Roelof A., van Dissel, Jaap T., van de Vosse, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria CD56 antigen Cytokines Dendritic cells Feedback loops Granulocyte-macrophage colony-stimulating factor Immune response Immune system Immunity Immunology Immunology/Immune Response Immunology/Immunity to Infections Immunology/Innate Immunity Immunology/Leukocyte Activation Infections Infectious diseases Inflammation Interferon Interleukin Interleukin 12 Interleukin 18 Interleukin 23 Lymphocytes Lymphocytes T Macrophages Monocytes Pattern recognition Pattern recognition receptors Penicillin Positive feedback Receptors Regulation Salmonella Tuberculosis Tumor necrosis factor-TNF γ-Interferon
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