Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes

The immune cells named T lymphocytes circulate around the body fulfilling their role in immunosurveillance by monitoring the tissues for injury or infection. To migrate from the blood into the tissues, they make use of the integrin LFA-1 which is exclusively expressed by immune cells. These highly m...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e15090-e15090
Hauptverfasser:	Svensson, Lena, McDowall, Alison, Giles, Katherine M, Stanley, Paula, Feske, Stefan, Hogg, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesions Biology Blood Blotting, Western Calcium Calcium (extracellular) Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium channels Calcium Channels - genetics Calcium Channels - metabolism Calcium influx Calpain Calpain - genetics Calpain - metabolism Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Cells, Cultured Cysteine Cysteine proteinase Cystine Dismantling Elongation Enzyme Activation - drug effects Fluorescence Health aspects Humans Imidazoles - pharmacology Immune system Immunohistochemistry Immunosurveillance Inhibition Integrins Intercellular adhesion molecule 1 Ion channels Kinases LFA-1 antigen Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes Lymphocytes T Microscopy, Confocal Microscopy, Video Mutation ORAI1 Protein Pharmacology RNA Interference Rodents Shedding Signaling siRNA Substrates T cell receptors T cells T-Lymphocytes - drug effects T-Lymphocytes - metabolism Tissues TRAIL protein Trailing edges
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