Dorsal visual pathway changes in patients with comitant extropia
Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combine...
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| Veröffentlicht in: | PloS one 2010-06, Vol.5 (6), p.e10931-e10931 |
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| creator | Yan, Xiaohe Lin, Xiaoming Wang, Qifeng Zhang, Yuanchao Chen, Yingming Song, Shaojie Jiang, Tianzi |
| description | Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combined T1-weighted imaging and diffusion tensor imaging (DTI).
Thirteen patients with comitant strabismus and twelve controls underwent magnetic resonance imaging (MRI) with acquisition of T1-weighted and diffusion tensor images. T1-weighted images were used to analyze the change in volume of white matter using optimized voxel-based morphology (VBM) and diffusion tensor images were used to detect the change in white matter fibers using voxel-based analysis of DTI in comitant extropia patients. VBM analysis showed that in adult strabismus, white matter volumes were smaller in the right middle occipital gyrus, right occipital lobe/cuneus, right supramarginal gyrus, right cingulate gyrus, right frontal lobe/sub-gyral, right inferior temporal gyrus, left parahippocampa gyrus, left cingulate gyrus, left occipital lobe/cuneus, left middle frontal gyrus, left inferior parietal lobule, and left postcentral gyrus, while no brain region with greater white matter volume was found. Voxel-based analysis of DTI showed lower fractional anisotropy (FA) values in the right middle occipital gyrus and right supramarginal gyrus in strabismus patients, while brain region with increased FA value was found in the right inferior frontal gyrus.
By combining VBM and voxel-based analysis of DTI results, the study suggests that the dorsal visual pathway was abnormal or impaired in patients with comitant exotropia. |
| doi_str_mv | 10.1371/journal.pone.0010931 |
| format | Article |
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Thirteen patients with comitant strabismus and twelve controls underwent magnetic resonance imaging (MRI) with acquisition of T1-weighted and diffusion tensor images. T1-weighted images were used to analyze the change in volume of white matter using optimized voxel-based morphology (VBM) and diffusion tensor images were used to detect the change in white matter fibers using voxel-based analysis of DTI in comitant extropia patients. VBM analysis showed that in adult strabismus, white matter volumes were smaller in the right middle occipital gyrus, right occipital lobe/cuneus, right supramarginal gyrus, right cingulate gyrus, right frontal lobe/sub-gyral, right inferior temporal gyrus, left parahippocampa gyrus, left cingulate gyrus, left occipital lobe/cuneus, left middle frontal gyrus, left inferior parietal lobule, and left postcentral gyrus, while no brain region with greater white matter volume was found. Voxel-based analysis of DTI showed lower fractional anisotropy (FA) values in the right middle occipital gyrus and right supramarginal gyrus in strabismus patients, while brain region with increased FA value was found in the right inferior frontal gyrus.
By combining VBM and voxel-based analysis of DTI results, the study suggests that the dorsal visual pathway was abnormal or impaired in patients with comitant exotropia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0010931</identifier><identifier>PMID: 20532166</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Anisotropy ; Brain ; Change detection ; Diffusion ; Exotropia - physiopathology ; Eye (anatomy) ; Female ; Fibers ; Frontal gyrus ; Frontal lobe ; Humans ; Image acquisition ; Image detection ; Laboratories ; Magnetic resonance ; Magnetic resonance imaging ; Male ; Medical research ; Nervous system ; Neuroimaging ; Neurological disorders ; Neurological Disorders/Neuro-Ophthalmology and Neuro-Otology ; Neuroscience/Sensory Systems ; NMR ; Nuclear magnetic resonance ; Occipital lobe ; Ophthalmology ; Ophthalmology/Pediatric Ophthalmology ; Patients ; Pattern recognition ; Postcentral gyrus ; Radiology and Medical Imaging/Magnetic Resonance Imaging ; Singers ; Strabismus ; Studies ; Substantia alba ; Temporal gyrus ; Visual Pathways</subject><ispartof>PloS one, 2010-06, Vol.5 (6), p.e10931-e10931</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Yan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Yan et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c723t-258436156be76eeb32fa7ca3861256438c5662d786ac6903ef27400aca25e2e83</citedby><cites>FETCH-LOGICAL-c723t-258436156be76eeb32fa7ca3861256438c5662d786ac6903ef27400aca25e2e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880591/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880591/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20532166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yang, Shaolin</contributor><creatorcontrib>Yan, Xiaohe</creatorcontrib><creatorcontrib>Lin, Xiaoming</creatorcontrib><creatorcontrib>Wang, Qifeng</creatorcontrib><creatorcontrib>Zhang, Yuanchao</creatorcontrib><creatorcontrib>Chen, Yingming</creatorcontrib><creatorcontrib>Song, Shaojie</creatorcontrib><creatorcontrib>Jiang, Tianzi</creatorcontrib><title>Dorsal visual pathway changes in patients with comitant extropia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combined T1-weighted imaging and diffusion tensor imaging (DTI).
Thirteen patients with comitant strabismus and twelve controls underwent magnetic resonance imaging (MRI) with acquisition of T1-weighted and diffusion tensor images. T1-weighted images were used to analyze the change in volume of white matter using optimized voxel-based morphology (VBM) and diffusion tensor images were used to detect the change in white matter fibers using voxel-based analysis of DTI in comitant extropia patients. VBM analysis showed that in adult strabismus, white matter volumes were smaller in the right middle occipital gyrus, right occipital lobe/cuneus, right supramarginal gyrus, right cingulate gyrus, right frontal lobe/sub-gyral, right inferior temporal gyrus, left parahippocampa gyrus, left cingulate gyrus, left occipital lobe/cuneus, left middle frontal gyrus, left inferior parietal lobule, and left postcentral gyrus, while no brain region with greater white matter volume was found. Voxel-based analysis of DTI showed lower fractional anisotropy (FA) values in the right middle occipital gyrus and right supramarginal gyrus in strabismus patients, while brain region with increased FA value was found in the right inferior frontal gyrus.
By combining VBM and voxel-based analysis of DTI results, the study suggests that the dorsal visual pathway was abnormal or impaired in patients with comitant exotropia.</description><subject>Adult</subject><subject>Anisotropy</subject><subject>Brain</subject><subject>Change detection</subject><subject>Diffusion</subject><subject>Exotropia - physiopathology</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Fibers</subject><subject>Frontal gyrus</subject><subject>Frontal lobe</subject><subject>Humans</subject><subject>Image acquisition</subject><subject>Image detection</subject><subject>Laboratories</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Nervous system</subject><subject>Neuroimaging</subject><subject>Neurological disorders</subject><subject>Neurological Disorders/Neuro-Ophthalmology and Neuro-Otology</subject><subject>Neuroscience/Sensory 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visual pathway changes in patients with comitant extropia</title><author>Yan, Xiaohe ; Lin, Xiaoming ; Wang, Qifeng ; Zhang, Yuanchao ; Chen, Yingming ; Song, Shaojie ; Jiang, Tianzi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c723t-258436156be76eeb32fa7ca3861256438c5662d786ac6903ef27400aca25e2e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Anisotropy</topic><topic>Brain</topic><topic>Change detection</topic><topic>Diffusion</topic><topic>Exotropia - physiopathology</topic><topic>Eye (anatomy)</topic><topic>Female</topic><topic>Fibers</topic><topic>Frontal gyrus</topic><topic>Frontal lobe</topic><topic>Humans</topic><topic>Image acquisition</topic><topic>Image detection</topic><topic>Laboratories</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Nervous 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Xiaohe</au><au>Lin, Xiaoming</au><au>Wang, Qifeng</au><au>Zhang, Yuanchao</au><au>Chen, Yingming</au><au>Song, Shaojie</au><au>Jiang, Tianzi</au><au>Yang, Shaolin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dorsal visual pathway changes in patients with comitant extropia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-06-03</date><risdate>2010</risdate><volume>5</volume><issue>6</issue><spage>e10931</spage><epage>e10931</epage><pages>e10931-e10931</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Strabismus is a disorder in which the eyes are misaligned. Persistent strabismus can lead to stereopsis impairment. The effect of strabismus on human brain is not unclear. The present study is to investigate whether the brain white structures of comitant exotropia patients are impaired using combined T1-weighted imaging and diffusion tensor imaging (DTI).
Thirteen patients with comitant strabismus and twelve controls underwent magnetic resonance imaging (MRI) with acquisition of T1-weighted and diffusion tensor images. T1-weighted images were used to analyze the change in volume of white matter using optimized voxel-based morphology (VBM) and diffusion tensor images were used to detect the change in white matter fibers using voxel-based analysis of DTI in comitant extropia patients. VBM analysis showed that in adult strabismus, white matter volumes were smaller in the right middle occipital gyrus, right occipital lobe/cuneus, right supramarginal gyrus, right cingulate gyrus, right frontal lobe/sub-gyral, right inferior temporal gyrus, left parahippocampa gyrus, left cingulate gyrus, left occipital lobe/cuneus, left middle frontal gyrus, left inferior parietal lobule, and left postcentral gyrus, while no brain region with greater white matter volume was found. Voxel-based analysis of DTI showed lower fractional anisotropy (FA) values in the right middle occipital gyrus and right supramarginal gyrus in strabismus patients, while brain region with increased FA value was found in the right inferior frontal gyrus.
By combining VBM and voxel-based analysis of DTI results, the study suggests that the dorsal visual pathway was abnormal or impaired in patients with comitant exotropia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20532166</pmid><doi>10.1371/journal.pone.0010931</doi><tpages>e10931</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Anisotropy Brain Change detection Diffusion Exotropia - physiopathology Eye (anatomy) Female Fibers Frontal gyrus Frontal lobe Humans Image acquisition Image detection Laboratories Magnetic resonance Magnetic resonance imaging Male Medical research Nervous system Neuroimaging Neurological disorders Neurological Disorders/Neuro-Ophthalmology and Neuro-Otology Neuroscience/Sensory Systems NMR Nuclear magnetic resonance Occipital lobe Ophthalmology Ophthalmology/Pediatric Ophthalmology Patients Pattern recognition Postcentral gyrus Radiology and Medical Imaging/Magnetic Resonance Imaging Singers Strabismus Studies Substantia alba Temporal gyrus Visual Pathways |
| title | Dorsal visual pathway changes in patients with comitant extropia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T00%3A45%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dorsal%20visual%20pathway%20changes%20in%20patients%20with%20comitant%20extropia&rft.jtitle=PloS%20one&rft.au=Yan,%20Xiaohe&rft.date=2010-06-03&rft.volume=5&rft.issue=6&rft.spage=e10931&rft.epage=e10931&rft.pages=e10931-e10931&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0010931&rft_dat=%3Cgale_plos_%3EA473893153%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292419284&rft_id=info:pmid/20532166&rft_galeid=A473893153&rft_doaj_id=oai_doaj_org_article_900cf69e24d94275860eddf4d10043ab&rfr_iscdi=true |