Matrix rigidity regulates cancer cell growth and cellular phenotype

The mechanical properties of the extracellular matrix have an important role in cell growth and differentiation. However, it is unclear as to what extent cancer cells respond to changes in the mechanical properties (rigidity/stiffness) of the microenvironment and how this response varies among cance...

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Veröffentlicht in:	PloS one 2010-09, Vol.5 (9), p.e12905-e12905
Hauptverfasser:	Tilghman, Robert W, Cowan, Catharine R, Mih, Justin D, Koryakina, Yulia, Gioeli, Daniel, Slack-Davis, Jill K, Blackman, Brett R, Tschumperlin, Daniel J, Parsons, J Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Biological properties Biomechanical Phenomena Biotechnology Cancer Cell adhesion & migration Cell Biology/Cell Adhesion Cell Biology/Cell Growth and Division Cell Biology/Cell Signaling Cell Biology/Extra-Cellular Matrix Cell culture Cell differentiation Cell growth Cell Line, Tumor Cell Movement Cell Proliferation E-cadherin Epidermal growth factor Extracellular matrix Extracellular Matrix - chemistry Extracellular Matrix - metabolism Gels Genetic aspects Growth Humans Kinases Lung cancer Lung carcinoma Lungs Mechanical properties Mesenchyme Mice Neoplasms - genetics Neoplasms - metabolism Neoplasms - physiopathology Oncology Polyacrylamide Rigidity Rodents Stem cells Stiffness Substrates Three dimensional models Tumor cell lines Tumor cells
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