A predictive phosphorylation signature of lung cancer

Aberrant activation of signaling pathways drives many of the fundamental biological processes that accompany tumor initiation and progression. Inappropriate phosphorylation of intermediates in these signaling pathways are a frequently observed molecular lesion that accompanies the undesirable activa...

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Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7994-e7994
Hauptverfasser:	Wu, Chang-Jiun, Cai, Tianxi, Rikova, Klarisa, Merberg, David, Kasif, Simon, Steffen, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Biological activity Biomedical engineering Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Classification Computational Biology/Signaling Networks Computer applications Development and progression Disease Enzyme Inhibitors - pharmacology Feasibility studies Gene Expression Regulation, Neoplastic Genetics and Genomics/Bioinformatics Humans Intermediates Kinases Lung cancer Lung diseases Lung Neoplasms - metabolism Mass spectrometry Models, Biological Molecular Biology/Bioinformatics Multivariate Analysis Mutation Pathways Phenotype Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Proteins Proteomics Quantitative analysis Reproducibility of Results Scientific imaging Signal Transduction Signaling Signatures Software Tyrosine Tyrosine - chemistry
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