Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation

Tyrosine hydroxylase (TH) regulates dopamine (DA) bioavailability. Its product, L-DOPA, is an established treatment for Parkinson's disease (PD), suggesting that TH regulation influences locomotion. Site-specific phosphorylation of TH at ser31 and ser40 regulates activity. No direct evidence sh...

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Veröffentlicht in:	PloS one 2009-12, Vol.4 (12), p.e8466-e8466
Hauptverfasser:	Salvatore, Michael F, Pruett, Brandon S, Spann, Sandy L, Dempsey, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Animal behavior Animals Bioavailability Biological Availability Biosynthesis Catecholamines Cell body Dihydroxyphenylalanine DNA damage Dopamine Dopamine - metabolism Growth factors Health sciences Hydroxylase Hydroxylases In vivo methods and tests Levodopa Locomotion Locomotor activity Longevity Medical treatment Metabolism Monkeys & apes Morphology Motor Activity - physiology Movement disorders Neostriatum Neurodegenerative diseases Neuropil Neuroscience Neuroscience/Behavioral Neuroscience Neuroscience/Motor Systems Neuroscience/Neuronal Signaling Mechanisms Neurosciences Nucleus accumbens Older people Parkinson's disease Pharmacology Phenols (Class of compounds) Phosphorylation Phosphoserine - metabolism Physiological aspects Physiology/Cell Signaling Physiology/Motor Systems Physiology/Neuronal Signaling Mechanisms Population Dynamics Proteins Rats Rats, Inbred F344 Rodents Substantia nigra Substantia Nigra - enzymology Toxicology Tyrosine Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - metabolism
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