Nicotinamide riboside kinase structures reveal new pathways to NAD

The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound...

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Veröffentlicht in:	PLoS Biol 2007-10, Vol.5 (10), p.e263-e263
Hauptverfasser:	Tempel, Wolfram, Rabeh, Wael M, Bogan, Katrina L, Belenky, Peter, Wojcik, Marzena, Seidle, Heather F, Nedyalkova, Lyudmila, Yang, Tianle, Sauve, Anthony A, Park, Hee-Won, Brenner, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biochemistry Cell Biology Enzymes Genetics and Genomics Human Humans Kinases Medical research Molecular Sequence Data NAD - metabolism Nutrition Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Conformation Proteins Yeast
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