Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. For example, Lrp4 binds Wise, a secreted Wnt modulator and BMP antagonist. Lrp4 shares structural elements within the extracellular ligand bin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7930-e7930
Hauptverfasser:	Choi, Hong Y, Dieckmann, Marco, Herz, Joachim, Niemeier, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Analysis Animals Atherosclerosis Biochemistry/Cell Signaling and Trafficking Structures Biocompatibility Biomedical materials Bone and Bones Bone density Bone Development - genetics Bone growth Bone mineral content Bone mineral density Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Bone turnover Cancellous bone Cell Line Cellular signal transduction Chromosome 17 Computed tomography Deficient mutant Dkk1 protein Femur Gene Expression Regulation Genetic Markers Genetics and Genomics/Disease Models Genome-wide association studies Genomes Genomics Genotype & phenotype Glycoproteins Growth Humans Inhibitors Intercellular Signaling Peptides and Proteins - metabolism Kinases LDL-Receptor Related Proteins - metabolism LRP5 protein Marfan syndrome Metabolism Mice Mutants Mutation Osteoblasts Osteoblasts - metabolism Osteocalcin Osteogenesis Osteoporosis Phenotype Phosphatases Physiology Proteins Receptor density Receptors Receptors, LDL - metabolism Rheumatology/Bone and Mineral Metabolism Rodents Signal Transduction Signaling Single nucleotide polymorphisms Single-nucleotide polymorphism SOST protein Spine Spine (lumbar) Structural members Transgenic animals Wnt protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!