Human microglia transplanted in rat focal ischemia brain induce neuroprotection and behavioral improvement

Microglia are resident immunocompetent and phagocytic cells of central nervous system (CNS), which produce various cytokines and growth factors in response to injury and thereby regulate disease pathology. The purpose of this study is to investigate the effects of microglial transplantation on focal...

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Veröffentlicht in:	PloS one 2010-07, Vol.5 (7), p.e11746-e11746
Hauptverfasser:	Narantuya, Dashdemberel, Nagai, Atsushi, Sheikh, Abdullah Md, Masuda, Junichi, Kobayashi, Shotai, Yamaguchi, Shuhei, Kim, Seung U
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Astrocytes Bone marrow Brain Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - therapy Brain research Brain-derived neurotrophic factor Carotid arteries Cell culture Cell Line Cell migration Cell survival Central nervous system Cerebral blood flow Chemokines Cytokines Cytokines - metabolism Disease Gene expression Glial cell line-derived neurotrophic factor Glial cells Gliosis Growth factors Human behavior Humans Immunohistochemistry Inflammation Interleukin 4 Interleukin 5 Ischemia Laboratories Macrophages Male Medical research Medicine Microdissection Microglia Microglia - cytology Nerve Growth Factors - metabolism Neurogenesis Neurological Disorders/Cerebrovascular Disease Neurology Neuromodulation Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neuronal and Glial Cell Biology Occlusion Polymerase Chain Reaction Random Allocation Rats Rats, Sprague-Dawley Recovery of function Rodents Stem cell transplantation Stem cells Stroke Tetrazolium Salts Transplantation Tumor necrosis factor-TNF Vascular endothelial growth factor Veins & arteries
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