Heterosexual and homosexual partners practising unprotected sex may develop allogeneic immunity and to a lesser extent tolerance
Epidemiological studies suggest that allogeneic immunity may inhibit HIV-1 transmission from mother to baby and is less frequent in multiparous than uniparous women. Alloimmune responses may also be elicited during unprotected heterosexual intercourse, which is associated ex vivo with resistance to...
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| Veröffentlicht in: | PloS one 2009-11, Vol.4 (11), p.e7938-e7938 |
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| creator | Kingsley, Cherry Peters, Barry Babaahmady, Kaboutar Pomeroy, Laura Rahman, Durdana Vaughan, Robert Lehner, Thomas |
| description | Epidemiological studies suggest that allogeneic immunity may inhibit HIV-1 transmission from mother to baby and is less frequent in multiparous than uniparous women. Alloimmune responses may also be elicited during unprotected heterosexual intercourse, which is associated ex vivo with resistance to HIV infection.
The investigation was carried out in well-defined heterosexual and homosexual monogamous partners, practising unprotected sex and a heterosexual cohort practising protected sex. Allogeneic CD4(+) and CD8(+) T cell proliferative responses were elicited by stimulating PBMC with the partners' irradiated monocytes and compared with 3(rd) party unrelated monocytes, using the CFSE method. Significant increase in allogeneic proliferative responses was found in the CD4(+) and CD8(+) T cells to the partners' irradiated monocytes, as compared with 3(rd) party unrelated monocytes (p |
| doi_str_mv | 10.1371/journal.pone.0007938 |
| format | Article |
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The investigation was carried out in well-defined heterosexual and homosexual monogamous partners, practising unprotected sex and a heterosexual cohort practising protected sex. Allogeneic CD4(+) and CD8(+) T cell proliferative responses were elicited by stimulating PBMC with the partners' irradiated monocytes and compared with 3(rd) party unrelated monocytes, using the CFSE method. Significant increase in allogeneic proliferative responses was found in the CD4(+) and CD8(+) T cells to the partners' irradiated monocytes, as compared with 3(rd) party unrelated monocytes (p<or=0.001). However, a significant decrease in proliferative responses, especially of CD8(+) T cells to the partners' compared with 3(rd) party monocytes was consistent with tolerization, in both the heterosexual and homosexual partners (p<0.01). Examination of CD4(+)CD25(+)FoxP3(+) regulatory T cells by flow cytometry revealed a significantly greater proportion of these cells in the homosexual than heterosexual partners practising unprotected sex (p<0.05). Ex vivo studies of infectivity of PBMC with HIV-1 showed significantly greater inhibition of infectivity of PBMC from heterosexual subjects practising unprotected compared with those practising protected sex (p = 0.02).
Both heterosexual and homosexual monogamous partners practising unprotected sex develop allogeneic CD4(+) and CD8(+) T cell proliferative responses to the partners' unmatched cells and a minority may be tolerized. However, a greater proportion of homosexual rather than heterosexual partners developed CD4(+)CD25FoxP3(+) regulatory T cells. These results, in addition to finding greater inhibition of HIV-1 infectivity in PBMC ex vivo in heterosexual partners practising unprotected, compared with those practising protected sex, suggest that allogeneic immunity may play a significant role in the immuno-pathogenesis of HIV-1 infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0007938</identifier><identifier>PMID: 19956755</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; B cells ; CD25 antigen ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Chemokines ; Cohort Studies ; Comparative analysis ; Cytometry ; Dendritic cells ; Disease transmission ; Epidemiology ; Female ; Flow cytometry ; Forkhead Transcription Factors - metabolism ; Foxp3 protein ; Heterosexuality ; HIV ; HIV infections ; HIV Infections - immunology ; Homosexuality ; Hospitals ; Human immunodeficiency virus ; Humans ; Immune System ; Immune Tolerance - immunology ; Immunity ; Immunological tolerance ; Immunology ; Immunology/Immune Response ; Immunology/Innate Immunity ; Immunoregulation ; Infections ; Infectious diseases ; Infectious Diseases/HIV Infection and AIDS ; Infectivity ; Inhibition ; Interleukin-2 Receptor alpha Subunit - biosynthesis ; Leukocytes, Mononuclear - cytology ; Lymphocytes ; Lymphocytes T ; Male ; Monocytes ; Pathogenesis ; Peripheral blood mononuclear cells ; Preeclampsia ; Sex ; Sex industry ; T cell receptors ; T cells ; Transplants & implants ; Unsafe Sex</subject><ispartof>PloS one, 2009-11, Vol.4 (11), p.e7938-e7938</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Kingsley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Kingsley et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c663t-62622f7fb03ab5871acfb8f13587a58e00e88d96e0800a5dd7346b597912c34e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775923/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775923/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19956755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Unutmaz, Derya</contributor><creatorcontrib>Kingsley, Cherry</creatorcontrib><creatorcontrib>Peters, Barry</creatorcontrib><creatorcontrib>Babaahmady, Kaboutar</creatorcontrib><creatorcontrib>Pomeroy, Laura</creatorcontrib><creatorcontrib>Rahman, Durdana</creatorcontrib><creatorcontrib>Vaughan, Robert</creatorcontrib><creatorcontrib>Lehner, Thomas</creatorcontrib><title>Heterosexual and homosexual partners practising unprotected sex may develop allogeneic immunity and to a lesser extent tolerance</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Epidemiological studies suggest that allogeneic immunity may inhibit HIV-1 transmission from mother to baby and is less frequent in multiparous than uniparous women. Alloimmune responses may also be elicited during unprotected heterosexual intercourse, which is associated ex vivo with resistance to HIV infection.
The investigation was carried out in well-defined heterosexual and homosexual monogamous partners, practising unprotected sex and a heterosexual cohort practising protected sex. Allogeneic CD4(+) and CD8(+) T cell proliferative responses were elicited by stimulating PBMC with the partners' irradiated monocytes and compared with 3(rd) party unrelated monocytes, using the CFSE method. Significant increase in allogeneic proliferative responses was found in the CD4(+) and CD8(+) T cells to the partners' irradiated monocytes, as compared with 3(rd) party unrelated monocytes (p<or=0.001). However, a significant decrease in proliferative responses, especially of CD8(+) T cells to the partners' compared with 3(rd) party monocytes was consistent with tolerization, in both the heterosexual and homosexual partners (p<0.01). Examination of CD4(+)CD25(+)FoxP3(+) regulatory T cells by flow cytometry revealed a significantly greater proportion of these cells in the homosexual than heterosexual partners practising unprotected sex (p<0.05). Ex vivo studies of infectivity of PBMC with HIV-1 showed significantly greater inhibition of infectivity of PBMC from heterosexual subjects practising unprotected compared with those practising protected sex (p = 0.02).
Both heterosexual and homosexual monogamous partners practising unprotected sex develop allogeneic CD4(+) and CD8(+) T cell proliferative responses to the partners' unmatched cells and a minority may be tolerized. However, a greater proportion of homosexual rather than heterosexual partners developed CD4(+)CD25FoxP3(+) regulatory T cells. 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immunology</subject><subject>Homosexuality</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune System</subject><subject>Immune Tolerance - immunology</subject><subject>Immunity</subject><subject>Immunological tolerance</subject><subject>Immunology</subject><subject>Immunology/Immune Response</subject><subject>Immunology/Innate Immunity</subject><subject>Immunoregulation</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Infectious Diseases/HIV Infection and AIDS</subject><subject>Infectivity</subject><subject>Inhibition</subject><subject>Interleukin-2 Receptor alpha Subunit - biosynthesis</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Monocytes</subject><subject>Pathogenesis</subject><subject>Peripheral blood mononuclear cells</subject><subject>Preeclampsia</subject><subject>Sex</subject><subject>Sex industry</subject><subject>T cell receptors</subject><subject>T cells</subject><subject>Transplants & implants</subject><subject>Unsafe Sex</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQgJx2MWx4zi-IFUV0JUqVeLrajn2ZNeVYwfbqbo3fjpuN4VdxAHlYHv8zOuZyUxRPK_QsiKsenflp-CkXY7ewRIhxDhpHxTHFSd40WBEHu7tj4onMV4hREnbNI-Lo4pz2jBKj4uf55Ag-Ag3k7SldLrc-OH-OMqQHIRYjkGqZKJx63JyY_AJVAJdZqwc5LbUcA3Wj6W01q_BgVGlGYbJmbS9k0y-lKWFGCGUcJPApWyyEKRT8LR41Esb4dm8nhTfPn74ena-uLj8tDo7vViopiEpZ9Fg3LO-Q0R2tGWVVH3X9hXJe0lbQAjaVvMGUIuQpFozUjcd5YxXWJEayEnxcqc7Wh_FXLwoKswxQRg3dSZWO0J7eSXGYAYZtsJLI-4MPqxFrodRFoSiWLGaqg4wqZVSXGqKet3lUABpXGWt9_NrUzeAVjnlIO2B6OGNMxux9tcCM0ZzRFngzSwQ_I8JYhKDiQqslQ78FAUjhLe8ISiTr_4i_53ccketZY7fuN7nZ1X-NAxG5RbqTbaf1gwzziij2eHtgUNmUv53aznFKFZfPv8_e_n9kH29x25A2rSJ3k7JeBcPwXoHqtyeMUD_u3oVErcTcJ-nuJ0AMU9AdnuxX_k_TnPLk18E6gU4</recordid><startdate>20091123</startdate><enddate>20091123</enddate><creator>Kingsley, Cherry</creator><creator>Peters, Barry</creator><creator>Babaahmady, Kaboutar</creator><creator>Pomeroy, Laura</creator><creator>Rahman, Durdana</creator><creator>Vaughan, Robert</creator><creator>Lehner, Thomas</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20091123</creationdate><title>Heterosexual and homosexual partners practising unprotected sex may develop allogeneic immunity and to a lesser extent tolerance</title><author>Kingsley, Cherry ; Peters, Barry ; Babaahmady, Kaboutar ; Pomeroy, Laura ; Rahman, Durdana ; Vaughan, Robert ; Lehner, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c663t-62622f7fb03ab5871acfb8f13587a58e00e88d96e0800a5dd7346b597912c34e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>B cells</topic><topic>CD25 antigen</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - 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Alloimmune responses may also be elicited during unprotected heterosexual intercourse, which is associated ex vivo with resistance to HIV infection.
The investigation was carried out in well-defined heterosexual and homosexual monogamous partners, practising unprotected sex and a heterosexual cohort practising protected sex. Allogeneic CD4(+) and CD8(+) T cell proliferative responses were elicited by stimulating PBMC with the partners' irradiated monocytes and compared with 3(rd) party unrelated monocytes, using the CFSE method. Significant increase in allogeneic proliferative responses was found in the CD4(+) and CD8(+) T cells to the partners' irradiated monocytes, as compared with 3(rd) party unrelated monocytes (p<or=0.001). However, a significant decrease in proliferative responses, especially of CD8(+) T cells to the partners' compared with 3(rd) party monocytes was consistent with tolerization, in both the heterosexual and homosexual partners (p<0.01). Examination of CD4(+)CD25(+)FoxP3(+) regulatory T cells by flow cytometry revealed a significantly greater proportion of these cells in the homosexual than heterosexual partners practising unprotected sex (p<0.05). Ex vivo studies of infectivity of PBMC with HIV-1 showed significantly greater inhibition of infectivity of PBMC from heterosexual subjects practising unprotected compared with those practising protected sex (p = 0.02).
Both heterosexual and homosexual monogamous partners practising unprotected sex develop allogeneic CD4(+) and CD8(+) T cell proliferative responses to the partners' unmatched cells and a minority may be tolerized. However, a greater proportion of homosexual rather than heterosexual partners developed CD4(+)CD25FoxP3(+) regulatory T cells. These results, in addition to finding greater inhibition of HIV-1 infectivity in PBMC ex vivo in heterosexual partners practising unprotected, compared with those practising protected sex, suggest that allogeneic immunity may play a significant role in the immuno-pathogenesis of HIV-1 infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19956755</pmid><doi>10.1371/journal.pone.0007938</doi><tpages>e7938</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2009-11, Vol.4 (11), p.e7938-e7938 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult B cells CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Chemokines Cohort Studies Comparative analysis Cytometry Dendritic cells Disease transmission Epidemiology Female Flow cytometry Forkhead Transcription Factors - metabolism Foxp3 protein Heterosexuality HIV HIV infections HIV Infections - immunology Homosexuality Hospitals Human immunodeficiency virus Humans Immune System Immune Tolerance - immunology Immunity Immunological tolerance Immunology Immunology/Immune Response Immunology/Innate Immunity Immunoregulation Infections Infectious diseases Infectious Diseases/HIV Infection and AIDS Infectivity Inhibition Interleukin-2 Receptor alpha Subunit - biosynthesis Leukocytes, Mononuclear - cytology Lymphocytes Lymphocytes T Male Monocytes Pathogenesis Peripheral blood mononuclear cells Preeclampsia Sex Sex industry T cell receptors T cells Transplants & implants Unsafe Sex |
| title | Heterosexual and homosexual partners practising unprotected sex may develop allogeneic immunity and to a lesser extent tolerance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T01%3A59%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heterosexual%20and%20homosexual%20partners%20practising%20unprotected%20sex%20may%20develop%20allogeneic%20immunity%20and%20to%20a%20lesser%20extent%20tolerance&rft.jtitle=PloS%20one&rft.au=Kingsley,%20Cherry&rft.date=2009-11-23&rft.volume=4&rft.issue=11&rft.spage=e7938&rft.epage=e7938&rft.pages=e7938-e7938&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0007938&rft_dat=%3Cgale_plos_%3EA472797575%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292302264&rft_id=info:pmid/19956755&rft_galeid=A472797575&rft_doaj_id=oai_doaj_org_article_c52c745cbe234ccc9ad50fdb7a5e0d21&rfr_iscdi=true |