Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation

Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound d...

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Veröffentlicht in:	PloS one 2010-09, Vol.5 (9), p.e12733
Hauptverfasser:	Pointon, Amy V, Walker, Tracy M, Phillips, Kate M, Luo, Jinli, Riley, Joan, Zhang, Shu-Dong, Parry, Joel D, Lyon, Jonathan J, Marczylo, Emma L, Gant, Timothy W
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Triphosphate - metabolism Analysis Animals Anthracyclines Anticancer properties Apoptosis ATP Biochemical analysis Biochemistry/Transcription and Translation Biocompatibility Breast cancer Cancer Cancer treatment Cardiomyocytes Cardiotoxicity Cardiovascular Disorders/Cardiovascular Pharmacology Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Cell Line Chromatography Councils Damage Data processing Deoxyribonucleic acid DNA DNA biosynthesis DNA replication Doxorubicin Doxorubicin - pharmacology Drugs Electron effects Electron transport Electron Transport - drug effects Electron transport chain Electron Transport Chain Complex Proteins - genetics Electron Transport Chain Complex Proteins - metabolism Electrons Enzyme Activation - drug effects Gene expression Gene Expression - drug effects Genes Genetic research Genetics and Genomics/Functional Genomics Genetics and Genomics/Genomics Genetics and Genomics/Physiogenomics Genomes Genomic analysis Genomics Heart Heart - drug effects Heart diseases Hypotheses In vivo methods and tests Information management Mass spectrometry Medical diagnosis Medical research Metabolism Mice Mitochondria Myocardium - enzymology Myocardium - metabolism Ontology Protein Biosynthesis - drug effects Proteins Redox potential Redox properties RNA Scientific imaging Studies Toxicity Toxicology Transcription Transcription (Genetics) Translation Translation (Genetics) Urine
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