Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90

Background Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. Enhanced levels of HIF-1α, the oxygen-regulated subunit of HIF-1, is often associated with increased tumour angiogenesis, metastasis, therapeutic resistance and po...

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Veröffentlicht in:	PloS one 2010-07, Vol.5 (7), p.e11772
Hauptverfasser:	Trisciuoglio, Daniela, Gabellini, Chiara, Desideri, Marianna, Ziparo, Elio, Zupi, Gabriella, Del Bufalo, Donatella
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Bcl-2 protein Breast cancer Cell Biology/Cell Signaling Chemotherapy Degradation Embryology Genetics and Genomics/Gene Function Heat shock proteins Histology Hsp90 protein Hydroxylation Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factors Kinases Laboratories Melanoma Metastases Molecular Biology/Post-Translational Regulation of Gene Expression Neuroblastoma Oxygen Oxygen tension Pharmacology Post-translation Protein biosynthesis Protein expression Protein synthesis Proteins Rodents Stabilization Tumors Ubiquitin Vascular endothelial growth factor
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