Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Natural product structures have high chemical diversity and are attractive as lead structures for discovery of new drugs. One of the disease areas where natural products are most frequently used as therapeutics is oncology. A library of natural products (NCI Natural Product set) was screened for com...

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Veröffentlicht in:	PloS one 2009-10, Vol.4 (10), p.e7238-e7238
Hauptverfasser:	Fayad, Walid, Fryknäs, Mårten, Brnjic, Slavica, Olofsson, Maria Hägg, Larsson, Rolf, Linder, Stig
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animal models Animals Anthracyclines Antibiotics Antineoplastic Agents - pharmacology Apoptosis Ascochyta salicorniae Bax protein Biological Transport Cancer therapies Carcinoma - drug therapy Carcinoma - metabolism Caspase Cell culture Cell Line, Tumor Colon Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Croton Cytochrome Cytochrome c Cytotoxicity Deoxyribonucleic acid DNA DNA topoisomerase DNA topoisomerase (ATP-hydrolysing) Doxorubicin Drug discovery Drug Evaluation, Preclinical Drugs Efflux Etoposide FDA approval Gene expression Humans Inhibitors Material requirements planning MEDICIN MEDICINE Mice Mitochondria Mitoxantrone Natural products Neoplasm Transplantation Oncology Oncology/Gastrointestinal Cancers Oncology/Oncology Agents Pathology Pharmacology/Drug Development Pharmacology/Drug Resistance Phosphatase Plant Extracts - pharmacology Potassium Protein Conformation Proteins Spheroids Streptomyces Therapeutics Topoisomerase I Inhibitors Transcription factors Trees Xenografts
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