The compartmentalisation of phosphorylated free oligosaccharides in cells from a CDG Ig patient reveals a novel ER-to-cytosol translocation process

Biosynthesis of the dolichol linked oligosaccharide (DLO) required for protein N-glycosylation starts on the cytoplasmic face of the ER to give Man(5)GlcNAc(2)-PP-dolichol, which then flips into the ER for further glycosylation yielding mature DLO (Glc(3)Man(9)GlcNAc(2)-PP-dolichol). After transfer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2010-07, Vol.5 (7), p.e11675-e11675
Hauptverfasser:	Peric, Delphine, Durrant-Arico, Christelle, Delenda, Christophe, Dupré, Thierry, De Lonlay, Pascale, de Baulny, Hélène Ogier, Pelatan, Cécile, Bader-Meunier, Brigitte, Danos, Olivier, Chantret, Isabelle, Moore, Stuart E H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biochemistry/Chemical Biology of the Cell Biosynthesis Carbohydrate Metabolism, Inborn Errors - metabolism Cell Biology/Chemical Biology of the Cell Cell Biology/Membranes and Sorting Cell Line Cell Line, Tumor Cleavage Congenital diseases Cytosol Dolichol Endoplasmic reticulum Enzymes Genes Glycoproteins Glycosylation Hexose Humans Immunoglobulins Intermediates Kinetics Lipids Lymphoma - metabolism Mice Models, Biological Mutation Oligosaccharides Oligosaccharides - metabolism Patients Phosphorylation - physiology Polypeptides Protein biosynthesis Protein synthesis Protein transport Pyrophosphatase Saccharomyces cerevisiae Translocation Trends
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!