LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner

The Lymphoblastic leukemia 1 (LYL1) gene is a proto-oncogenic transcription factor found upregulated in patients with T-cell acute lymphoblastic leukemia (T-cell ALL). Initially, the upregulation was described to be as a result of a translocation. However, further studies revealed that transcription...

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Veröffentlicht in:	PloS one 2010-09, Vol.5 (9), p.e12692
Hauptverfasser:	Lukov, Georgi L, Goodell, Margaret A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Amino Acid Motifs Amino Acid Sequence Amino acids Basic Helix-Loop-Helix Transcription Factors - chemistry Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biochemistry Biodegradation Cancer Cell Biology/Cell Signaling Cell culture Cell cycle Cell Line Degradation Gene expression Genetic aspects Hematology/Bone Marrow and Stem Cell Transplantation Hematology/Hematopoiesis Humans Immunology/Leukocyte Development Kinases Leukemia Lymphatic leukemia Lymphocytes T MAP kinase Medicine Mitogen-Activated Protein Kinase Kinases - metabolism Molecular Biology/Post-Translational Regulation of Gene Expression Molecular Sequence Data N-Terminus Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Pediatrics Pests Phosphatase Phosphorylation Post-translation Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteasomes Protein transport Proteins Proteolysis Sequence Alignment Signal transduction Stem cells T cells Transcription (Genetics) Translation Translocation
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