Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity

Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma vaccine design has mainly focused on targeting CD8+ T cells. Activation of effe...

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Veröffentlicht in:	PloS one 2010-09, Vol.5 (9), p.e12670
Hauptverfasser:	Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F, Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N, Wolchok, Jedd D
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS vaccines Alphavirus Alphavirus - genetics Alphavirus - physiology Animals Anticancer properties Antigens Antitumor activity Cancer Cancer vaccines Cancer Vaccines - genetics Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cell Line, Tumor Cell-mediated immunity Chemotherapy Clinical trials Coding Cytomegalovirus Cytotoxicity Effector cells Female Gene Expression Genetic engineering Genetic Vectors - genetics Genetic Vectors - physiology Humans Humoral immunity Immunity Immunity, Cellular Immunity, Humoral Immunogenicity Immunoglobulin G Immunoglobulins Immunology Immunology/Immune Response Immunotherapy Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - immunology Intramolecular Oxidoreductases - therapeutic use Laboratories Lymphocytes Lymphocytes T Medical research Melanoma Melanoma - immunology Melanoma - prevention & control Melanoma - therapy Metastasis Mice Mice, Inbred C57BL Mice, Knockout Mutation Oncology Proteins Radiation therapy Receptors Replicon Signaling Skin cancer Skin diseases T cells Transgenic mice Tumors Tyrosinase Vaccines Vectors (Biology) Viruses
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