Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics

Staphylococcus aureus is a prominent human pathogen and leading cause of bacterial infection in hospitals and the community. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 are highly virulent and, unlike hospital strains, often cause disease in otherwise health...

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Veröffentlicht in:	PloS one 2010-07, Vol.5 (7), p.e11634-e11634
Hauptverfasser:	Ventura, Christy L, Malachowa, Natalia, Hammer, Carl H, Nardone, Glenn A, Robinson, Mary Ann, Kobayashi, Scott D, DeLeo, Frank R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bacteria Bacterial infections Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - pharmacology Bioinformatics Cell culture Cell Membrane - drug effects Cell surface Cells, Cultured Clonal deletion Communities Cross infection Culture media Cytolytic activity Drug resistance Electrophoresis, Polyacrylamide Gel Enzymes Exotoxins - genetics Exotoxins - metabolism Exotoxins - pharmacology Gene expression Genomes Granulocytes Health aspects Humans Identification Immune response Immune system Immunoblotting Immunology/Innate Immunity Infectious diseases Infectious Diseases/Bacterial Infections Innate immunity Laboratories Leukocytes (neutrophilic) Lysis Mass Spectrometry Mass spectroscopy Media (culture) Methicillin Microbiology/Innate Immunity Neutrophils Neutrophils - drug effects Pathogenesis Pathogens Peptides Phagocytosis Pore formation Protein A Proteins Proteomics Proteomics - methods Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus aureus - metabolism Staphylococcus aureus infections Staphylococcus infections Strains (organisms) Virulence Virulence (Microbiology)
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