The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants

The pathogenesis of immunodeficiency due to human immunodeficiency virus (HIV)-1 is incompletely understood, but immune activation is believed to play a central role. Immunomodulatory agents that decrease immune activation may be useful in the treatment of HIV-1 infection. A randomized, double blind...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e11937
Hauptverfasser:	Read, Sarah W, DeGrezia, Mary, Ciccone, Emily J, DerSimonian, Rebecca, Higgins, Jeanette, Adelsberger, Joseph W, Starling, Judith M, Rehm, Catherine, Sereti, Irini
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Apoptosis Bromodeoxyuridine Care and treatment CD38 antigen CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell activation Chronic infection Cycles Cytomegalovirus Drug-Related Side Effects and Adverse Reactions Female Health aspects Highly active antiretroviral therapy Histocompatibility antigen HLA HIV HIV Infections - immunology HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunologic Factors - adverse effects Immunologic Factors - metabolism Immunologic Factors - pharmacology Immunological memory Immunology Immunology/Immunomodulation Immunomodulation Infection Infectious Diseases/HIV Infection and AIDS Isoxazoles - adverse effects Isoxazoles - immunology Isoxazoles - metabolism Leflunomide Lymphocyte Count Lymphocytes Lymphocytes T Male Markers Medical research Memory cells Microorganisms Pathogenesis Peripheral blood Phenotype Randomization Receptors RNA, Viral - blood T cells T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology Translocation Viruses
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