Oxidative stress impairs the heat stress response and delays unfolded protein recovery

Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there have been few studies investigating their combined adverse effec...

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Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7719-e7719
Hauptverfasser:	Adachi, Masaaki, Liu, Yaohua, Fujii, Kyoko, Calderwood, Stuart K, Nakai, Akira, Imai, Kohzoh, Shinomura, Yasuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Animals Apoptosis Cell Biology/Cellular Death and Stress Responses Cell Biology/Gene Expression Cell death Cell Line, Tumor Cell Survival Climate change Deoxyribonucleic acid DNA DNA-Binding Proteins - metabolism Environmental changes Eukaryotic Initiation Factor-2 - metabolism Exposure Fever Fibroblasts - metabolism Global warming Heat shock Heat shock proteins Heat stress Heat tolerance Heat-Shock Response Heatstroke HSF1 protein HSP40 Heat-Shock Proteins - chemistry HSP40 Heat-Shock Proteins - metabolism Hsp40 protein HSP70 Heat-Shock Proteins - chemistry HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - chemistry Internal medicine Kinases Medicine Membrane potential Membrane Potential, Mitochondrial Mice Mitochondria Oncology Oxidative Stress Ozone Ozone depletion Ozone layer depletion Peroxides Phosphorylation Physiology/Cell Signaling Preconditioning Protein Denaturation Protein folding Protein synthesis Quality control Recovery Recovery (Medical) Regulatory Factor X Transcription Factors Sensitivity Sensitivity enhancement Splicing Transcription factors Transcription Factors - metabolism X-Box Binding Protein 1
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