Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands
The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. The entire mitochondrial genome of 22 salivary gland adenoid cy...
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| description | The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas.
The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.
Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex.
Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication. |
| doi_str_mv | 10.1371/journal.pone.0008493 |
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The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.
Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex.
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The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.
Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex.
Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication.</description><subject>Acids</subject><subject>Adenine</subject><subject>Adenoid</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aerobic respiration</subject><subject>Aged</subject><subject>Alterations</subject><subject>Amino acid sequence</subject><subject>Amino acids</subject><subject>Amino Acids - genetics</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Carcinoma</subject><subject>Carcinoma, Adenoid Cystic - genetics</subject><subject>Chemotherapy</subject><subject>Chromosomes</subject><subject>Cytochrome</subject><subject>Demography</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA, Mitochondrial - chemistry</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Female</subject><subject>Gene sequencing</subject><subject>Genetic aspects</subject><subject>Genetic testing</subject><subject>Genome, Mitochondrial</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Glands</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Male</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Mitochondrial DNA</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>NAD</subject><subject>NAD - metabolism</subject><subject>NADH</subject><subject>Niacinamide</subject><subject>Nicotinamide</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleotide sequence</subject><subject>Oncology</subject><subject>Oncology/Head and Neck Cancers</subject><subject>Oral cancer</subject><subject>Otolaryngology</subject><subject>Otolaryngology/Head and Neck Cancers</subject><subject>Proteins</subject><subject>Salivary gland</subject><subject>Salivary Gland Neoplasms - genetics</subject><subject>Salivary glands</subject><subject>Studies</subject><subject>Surgery</subject><subject>Transcription</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltrFDEUxwdRbK1-A9EBQfBh19xmsvMilOJlpVLw9hrO5DKTZTbZJpliv73Z7rTsPAgmDwknv_PPycm_KF5itMSU4_cbPwYHw3LnnV4ihFasoY-KU9xQsqgJoo-P9ifFsxg3CFV0VddPixOCEMN5nBZfv9nkZe-dChaGcjsmSNa7WFpXgtLOW1XK25isLCUEaZ3fQulNmXpdRhjsDYTbshvAqfi8eGJgiPrFtJ4Vvz59_HnxZXF59Xl9cX65kJw0aUERbalqgGlj6pU0kiCjK90iwlWFAGupW0JJa4gCYziRDUGS8woYRQxaoGfF64PubvBRTG2IApOGEFZhTDOxPhDKw0bsgt3mKoUHK-4CPnQCQn7SoEWNK9ly4EphyqjU0GBeQ0sZV6RekTprfZhuG9utVlK7FGCYic5PnO1F528E4U2F-b6YN5NA8NejjukfJS8PVAe5KuuMz2IyT6W3VuYvNjbHzxknnPGKkJzwbpaQmaT_pA7GGMX6x_f_Z69-z9m3R2yvYUh99MN454o5yA6gDD7GoM1DTzASe4fev1PsHSomh-a0V8f9fEi6tyT9Cylz4rI</recordid><startdate>20091230</startdate><enddate>20091230</enddate><creator>Mithani, Suhail K</creator><creator>Shao, Chunbo</creator><creator>Tan, Marietta</creator><creator>Smith, Ian M</creator><creator>Califano, Joseph A</creator><creator>El-Naggar, Adel K</creator><creator>Ha, Patrick K</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20091230</creationdate><title>Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands</title><author>Mithani, Suhail K ; Shao, Chunbo ; Tan, Marietta ; Smith, Ian M ; Califano, Joseph A ; El-Naggar, Adel K ; Ha, Patrick K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c729t-303b3d9a4eff68cfc20fe5eb027d50a1eceb232bf2daff72c920c775a4304aba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acids</topic><topic>Adenine</topic><topic>Adenoid</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aerobic respiration</topic><topic>Aged</topic><topic>Alterations</topic><topic>Amino acid sequence</topic><topic>Amino acids</topic><topic>Amino Acids - 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No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas.
The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.
Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex.
Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20041111</pmid><doi>10.1371/journal.pone.0008493</doi><tpages>e8493</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Adenine Adenoid Adolescent Adult Aerobic respiration Aged Alterations Amino acid sequence Amino acids Amino Acids - genetics Breast cancer Cancer Cancer therapies Carcinogenesis Carcinogens Carcinoma Carcinoma, Adenoid Cystic - genetics Chemotherapy Chromosomes Cytochrome Demography Deoxyribonucleic acid Diabetes DNA DNA damage DNA, Mitochondrial - chemistry DNA, Mitochondrial - genetics Female Gene sequencing Genetic aspects Genetic testing Genome, Mitochondrial Genomes Genomics Glands Humans Liver cancer Male Melanoma Metastasis Middle Aged Mitochondria Mitochondrial DNA Mutation Mutation - genetics NAD NAD - metabolism NADH Niacinamide Nicotinamide Nicotinamide adenine dinucleotide Nucleic Acid Conformation Nucleotide sequence Oncology Oncology/Head and Neck Cancers Oral cancer Otolaryngology Otolaryngology/Head and Neck Cancers Proteins Salivary gland Salivary Gland Neoplasms - genetics Salivary glands Studies Surgery Transcription Tumors Young Adult |
| title | Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands |
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