Fyn mediates leptin actions in the thymus of rodents

Several effects of leptin in the immune system rely on its capacity to modulate cytokine expression and apoptosis in the thymus. Surprisingly, some of these effects are dependent on signal transduction through the IRS1/PI3-kinase, but not on the activation of JAK2. Since all the well known effects o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7707-e7707
Hauptverfasser:	Girasol, Alessandra, Albuquerque, Gabriela G, Mansour, Eli, Araújo, Eliana P, Degasperi, Giovanna, Denis, Raphael G, Carvalheira, José B, Saad, Mário J, Velloso, Lício A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation Animal tissues Animals Antigens Apoptosis Cell Separation Cellular signal transduction Cytokines Diabetes and Endocrinology/Endocrinology Diabetes and Endocrinology/Obesity Experiments Fyn protein Gene Expression Regulation Genomes Immune system Immunology/Immunomodulation Immunomodulation Inhibition Insulin Internal medicine Janus kinase 2 Kinases Laboratories Leptin Leptin - physiology Ligands Lymphocytes Male Malnutrition Medicine Mice Mice, Inbred C57BL Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein expression Protein-tyrosine kinase Proteins Proto-Oncogene Proteins c-fyn - metabolism Rats Rats, Wistar Receptors, Leptin - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodentia Rodents Signal Transduction Signaling Thymus Thymus Gland - cytology Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!