Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor

The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2008-11, Vol.6 (11), p.e289-e289
Hauptverfasser:	Wang, LiMei, Rahn, Jennifer J, Lun, XueQing, Sun, Beichen, Kelly, John J P, Weiss, Samuel, Robbins, Stephen M, Forsyth, Peter A, Senger, Donna L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Animals Brain - metabolism Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - therapy Cell Biology Enzyme Inhibitors - therapeutic use Glioma - metabolism Glioma - therapy Humans Kinases Medical research Neoplasm Invasiveness - physiopathology Nerve Growth Factors - metabolism Neurological Disorders Neuroscience Proteins Receptor, Nerve Growth Factor - metabolism Recombinant Fusion Proteins Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!