Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells

Forkhead box p3 (Foxp3)-expressing regulatory T cells are key mediators of peripheral tolerance suppressing undesirable immune responses. Ectopic expression of Foxp3 confers regulatory T cell phenotype to conventional T cells, lending itself to therapeutic use in the prevention of autoimmunity and t...

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Veröffentlicht in:	PLoS biology 2008-11, Vol.6 (11), p.e276-e276
Hauptverfasser:	Andersen, Kristian G, Butcher, Tracey, Betz, Alexander G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Arthritis, Experimental - chemically induced Arthritis, Experimental - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Collagen Collagen - administration & dosage Diabetes Flow cytometry Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Genotype & phenotype Humans Immune system Immunology Immunosuppression Therapy Inflammatory bowel disease Leukemia Virus, Murine - genetics Lymphocyte Activation Lymphocytes Mice Mice, Inbred BALB C Mice, Inbred DBA Mice, SCID Multiple sclerosis Proteins Rheumatoid arthritis Rheumatology Rodents Spleen T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Transduction, Genetic
Online-Zugang:	Volltext
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