Multiple FadD acyl-CoA synthetases contribute to differential fatty acid degradation and virulence in Pseudomonas aeruginosa

A close interconnection between nutrient metabolism and virulence factor expression contributes to the pathophysiology of Pseudomonas aeruginosa as a successful pathogen. P. aeruginosa fatty acid (FA) degradation is complicated with multiple acyl-CoA synthetase homologs (FadDs) expressed in vivo in...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13557
Hauptverfasser:	Kang, Yun, Zarzycki-Siek, Jan, Walton, Chad B, Norris, Michael H, Hoang, Tung T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence AMP Analysis Base Sequence Biodegradation Bioengineering Biosynthesis Carbon sources Chains Cloning Coenzyme A Ligases - chemistry Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Cystic fibrosis Degradation Dehydrogenases DNA, Bacterial E coli Enzymes Escherichia coli Escherichia coli - enzymology FADD protein Fatty acids Fatty Acids - metabolism Fitness Genes Genetic aspects Genetics and Genomics/Gene Expression Genetics and Genomics/Gene Function Genomes Health aspects Homology Hydrolysis Infections Infectious Diseases/Bacterial Infections Infectious Diseases/Respiratory Infections Kinetics Lecithin Ligases Lipase Lipids Lungs Metabolism Microbiology/Microbial Physiology and Metabolism Molecular Sequence Data Motility Mutagenesis Mutants Mutation Nutrients Phosphatidylcholine Phospholipase Phospholipids Physical fitness Physiological aspects Plant engineering Proteases Proteins Pseudomonas Pseudomonas aeruginosa Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - pathogenicity RNA, Messenger - genetics Sequence Homology, Amino Acid Substrate Specificity Surfactants Swarming Swimming Tuberculosis Vectors (Biology) Virulence Virulence (Microbiology) Virulence factors
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