Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson's disease (PD). Here, we show that drinking H(2)-containing w...

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Veröffentlicht in:	PloS one 2009-09, Vol.4 (9), p.e7247
Hauptverfasser:	Fujita, Kyota, Seike, Toshihiro, Yutsudo, Noriko, Ohno, Mizuki, Yamada, Hidetaka, Yamaguchi, Hiroo, Sakumi, Kunihiko, Yamakawa, Yukiko, Kido, Mizuho A, Takaki, Atsushi, Katafuchi, Toshihiko, Tanaka, Yoshinori, Nakabeppu, Yusaku, Noda, Mami
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - analogs & derivatives 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - metabolism 4-Hydroxynonenal 8-Hydroxyguanine Animals Antioxidants Apoptosis Brain Brain injuries Brain injury Cancer Damage accumulation Deoxyribonucleic acid Disease Models, Animal DNA DNA damage Dopamine - metabolism Dopamine receptors Drinking water Genomics Head injuries Health aspects Hydrogen Hydrogen - chemistry Laboratories Lipid Peroxidation Mice Movement disorders MPTP Neostriatum Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurological diseases Neurological Disorders Neurons Neurons - metabolism Neuroscience/Neurobiology of Disease and Regeneration Neurotoxicity Nitric oxide Oxidative Stress Oxygen - chemistry Parkinson Disease - metabolism Parkinson's disease Pathology Peroxidation Pharmaceutical sciences Pharmacology Physiology Risk Risk reduction Rodents Superoxide Superoxides Tumorigenesis Water - metabolism Water Supply
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