Zeptomole electrochemical detection of metallothioneins

Thiol-rich peptides and proteins possess a large number of biological activities and may serve as markers for numerous health problems including cancer. Metallothionein (MT), a small molecular mass protein rich in cysteine, may be considered as one of the promising tumour markers. The aim of this pa...

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Veröffentlicht in:	PloS one 2010-07, Vol.5 (7), p.e11441
Hauptverfasser:	Adam, Vojtech, Petrlova, Jitka, Wang, Joseph, Eckschlager, Tomas, Trnkova, Libuse, Kizek, Rene
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorptivity Albumin Analysis Analytical methods Animals Biochemistry Biological products Blood Bovine serum albumin Breast cancer Cancer Carcinogenesis Carcinogens Cell Line Chemistry Chemistry/Physical, Inorganic, and Analytical Chemistry Cisplatin Coupling (molecular) Cysteine Cystine Detection limits Disease Electric properties Electrochemical analysis Electrochemistry Electrochemistry - methods Electrodes Electrolytes Electrophoresis, Polyacrylamide Gel Glutathione Health problems Heavy metals Humans Hypoxia Lab-on-a-chip Ligands Lymphoma Markers Mass spectrometry Metallothionein Metallothionein - blood Metallothionein - urine Metallothioneins Neuroblastoma Neuroblastoma cells Neuroblasts Oncology Oncology/Breast Cancer Peptides Potentiometry Prostate Proteins Rabbits Reproducibility of Results Scientific imaging Serum albumin Stripping Studies Transcription factors Tumors Voltammetry Yarrowia lipolytica Zinc
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