Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

Hypoxia-inducible factor-1 (HIF-1) plays a key role in cell adaptation to low oxygen and stabilization of HIF-1 is vital to ensure cell survival under hypoxia. Diabetes has been associated with impairment of the cell response to hypoxia and downregulation of HIF-1 is most likely the event that trans...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e15062
Hauptverfasser:	Bento, Carla Figueira, Fernandes, Rosa, Ramalho, José, Marques, Carla, Shang, Fu, Taylor, Allen, Pereira, Paulo, Ko, Ben C. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Biology Biomedical research Blotting, Western Cell death Cell Hypoxia Cell Line Cell Line, Tumor Cell survival cell viability Cercopithecus aethiops COS Cells Degradation Dehydrogenases Destabilization Diabetes Diabetes mellitus Fibroblasts Glucose Glucose - pharmacology HEK293 Cells Hepatitis HSP40 Heat-Shock Proteins - metabolism Hsp40 protein HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Hydroxylation Hyperglycemia Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - metabolism Hypoxia-inducible factors Intracellular Space - drug effects Intracellular Space - metabolism Ischemia Lactoylglutathione lyase Lactoylglutathione Lyase - genetics Lactoylglutathione Lyase - metabolism Light Medicine Molecular Chaperones - metabolism Motility Mutation Nutrition research Oxygen Peritoneal dialysis Proline Proteasomes Protein Binding Proteins Pyruvaldehyde Pyruvaldehyde - metabolism Pyruvaldehyde - pharmacology RNA Interference Rodents Transcription transcription (genetics) Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination - drug effects Ulcers Vascular endothelial growth factor Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism
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