Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings

Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be shortened leukocyte telomeres. When telomeres critically shorten, as often occurs with repeated mitoses or in response to oxidation an...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17837-e17837
Hauptverfasser:	Wolkowitz, Owen M, Mellon, Synthia H, Epel, Elissa S, Lin, Jue, Dhabhar, Firdaus S, Su, Yali, Reus, Victor I, Rosser, Rebecca, Burke, Heather M, Kupferman, Eve, Compagnone, Mariana, Nelson, J Craig, Blackburn, Elizabeth H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aging Alzheimer's disease Apoptosis Ascorbic acid Base pairs Biochemistry Biology Biophysics Brain Caregivers Case-Control Studies Chromosomes Chronic Disease Comparative analysis Correlation Cytokines Cytotoxicity Dementia Demography Deoxyribonucleic acid Depressive Disorder, Major - blood Depressive Disorder, Major - diagnosis Depressive Disorder, Major - genetics Depressive Disorder, Major - pathology DNA Eating disorders Exposure Female Genetic recombination Health aspects Health psychology Humans Hypotheses Illnesses Inflammation Inflammation - blood Inflammation - complications Inflammation - pathology Interleukin 6 Interleukin-6 - blood Leukocytes Leukocytes - metabolism Major depressive disorder Male Medical research Medicine Mental depression Middle Aged Mitosis Mortality Oxidation Oxidative Stress Prognosis Psychiatry Sex Characteristics Social and Behavioral Sciences Stroke Telomerase Telomere - metabolism Telomeres Vitamin C Yeast
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