Genome-wide association study identifies genetic loci associated with iron deficiency

The existence of multiple inherited disorders of iron metabolism in man, rodents and other vertebrates suggests genetic contributions to iron deficiency. To identify new genomic locations associated with iron deficiency, a genome-wide association study (GWAS) was performed using DNA collected from w...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e17390
Hauptverfasser:	McLaren, Christine E, Garner, Chad P, Constantine, Clare C, McLachlan, Stela, Vulpe, Chris D, Snively, Beverly M, Gordeuk, Victor R, Nickerson, Debbie A, Cook, James D, Leiendecker-Foster, Catherine, Beckman, Kenneth B, Eckfeldt, John H, Barcellos, Lisa F, Murray, Joseph A, Adams, Paul C, Acton, Ronald T, Killeen, Anthony A, McLaren, Gordon D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Anemia, Iron-Deficiency - genetics Biology Blood & organ donations Chromosome 7 Deoxyribonucleic acid DNA Epidemiology Ethnicity Female Ferritin Gene loci Gene polymorphism Genetic aspects Genetic Loci - genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Genomics Genotypes Health care facilities Health sciences Hemochromatosis Hemochromatosis - genetics Hereditary diseases HFE protein Humans Iron Iron - blood Iron deficiency Iron Overload - genetics Laboratories Loci Male Medicine Metabolism Middle Aged Mutation Nutrient deficiency Pathology Physiological aspects Polymorphism Polymorphism, Single Nucleotide - genetics Population (statistical) Public health Regression analysis Review boards Rodents Single nucleotide polymorphisms Single-nucleotide polymorphism Statistical analysis Statistical methods Target recognition Toxicology Transferrin Transferrins Vertebrates Veterans Women military personnel
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