Menin links the stress response to genome stability in Drosophila melanogaster

The multiple endocrine neoplasia type I gene functions as a tumor suppressor gene in humans and mouse models. In Drosophila melanogaster, mutants of the menin gene (Mnn1) are hypersensitive to mutagens or gamma irradiation and have profound defects in the response to several stresses including heat...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e14049
Hauptverfasser:	Papaconstantinou, Maria, Pepper, Alicia N, Wu, Ying, Kasimer, Dahlia, Westwood, Tim, Campos, Ana Regina, Bédard, Pierre-André
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Biology Cell Biology/Cellular Death and Stress Responses Cell division Cluster Analysis Control stability Deoxyribonucleic acid DNA DNA damage DNA repair Double-stranded RNA Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Epistasis Gamma irradiation Gamma rays Gene Deletion Gene expression Gene Expression Profiling Genes Genetic aspects Genetics and Genomics/Disease Models Genetics and Genomics/Gene Expression Genetics and Genomics/Gene Function Genome, Insect - genetics Genomes Genomic Instability Genomics Genotoxicity Heat shock proteins Heat-Shock Response - genetics Heterozygosity HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Hypoxia Insects Instability Ionizing radiation Irradiation Loss of Heterozygosity Mice Multiple endocrine neoplasia Mutagens Mutants Mutation Neuroendocrine tumors Oligonucleotide Array Sequence Analysis Osmotic pressure Oxidative stress Proteins RNA Interference Stability Stress response Tumor suppressor genes
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