Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies

β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and sequence diversity of Wnt isoforms suggest the possib...

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Veröffentlicht in:	PloS one 2010-09, Vol.5 (9), p.e12682
Hauptverfasser:	Gong, Yan, Bourhis, Eric, Chiu, Cecilia, Stawicki, Scott, DeAlmeida, Venita I, Liu, Bob Y, Phamluong, Khanhky, Cao, Tim C, Carano, Richard A D, Ernst, James A, Solloway, Mark, Rubinfeld, Bonnee, Hannoush, Rami N, Wu, Yan, Polakis, Paul, Costa, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal tissues Animals Antibodies - pharmacology Autocrine signalling Binding sites Biochemistry/Cell Signaling and Trafficking Structures Biotechnology Bone cancer Bone density Bone mineral density Bones Cancer Cell Biology/Cell Signaling Cell culture Cell Line Complexity Cytoplasmic membranes Dimerization Down-Regulation - drug effects Endoplasmic reticulum Engineering Heparan sulfate Humans Immunoglobulins Inhibition Isoforms Kinases LDL-Receptor Related Proteins - genetics LDL-Receptor Related Proteins - immunology LDL-Receptor Related Proteins - metabolism Ligands Low Density Lipoprotein Receptor-Related Protein-6 LRP5 protein LRP6 protein Mice Molecular biology Monoclonal antibodies Organ culture Phosphorylation Potentiation Protein binding Protein Binding - drug effects Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Recruitment Signal Transduction - drug effects Species Specificity Tumor cell lines Tyrosine Up-Regulation - drug effects Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism β-Catenin
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