PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness in humans. Previously, excessive activation of enzymes belonging to the poly-ADP-ribose polymerase (PARP) group was shown to be involved in photoreceptor degeneration in the hu...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e15495-e15495
Hauptverfasser:	Sahaboglu, Ayse, Tanimoto, Naoyuki, Kaur, Jasvir, Sancho-Pelluz, Javier, Huber, Gesine, Fahl, Edda, Arango-Gonzalez, Blanca, Zrenner, Eberhart, Ekström, Per, Löwenheim, Hubert, Seeliger, Mathias, Paquet-Durand, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Animal models Animals Apoptosis Biology Blindness Blotting, Western Cell death Clinical Medicine Comparative analysis Cyclic GMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism Degeneration Electroretinograms Electroretinography Enzymes Female Genetic aspects Genotypes Histology Homology Humans In Situ Nick-End Labeling In vivo methods and tests Inhibition Isoforms Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Mice Mice, 129 Strain Mice, Inbred C3H Mice, Knockout Monosaccharides Mortality Mutation Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurological diseases Oftalmologi Ophthalmology Phosphodiesterase Phosphodiesterase Inhibitors - pharmacology Photoreceptor Cells, Vertebrate - metabolism Photoreceptors Physiological aspects Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Purinones - pharmacology Retina Retina - enzymology Retina - metabolism Retina - physiopathology Retinal degeneration Retinal Degeneration - enzymology Retinal Degeneration - genetics Retinal Degeneration - pathology Retinitis Retinitis pigmentosa Retinitis Pigmentosa - enzymology Retinitis Pigmentosa - genetics Retinitis Pigmentosa - pathology Ribose Rodents Tomography, Optical Coherence
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