Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies

Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese....

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e14022-e14022
Hauptverfasser:	Xu, Min, Bi, Yufang, Xu, Yu, Yu, Bing, Huang, Yun, Gu, Lina, Wu, Yaohua, Zhu, Xiaolin, Li, Mian, Wang, Tiange, Song, Aiyun, Hou, Jianing, Li, Xiaoying, Ning, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asian Continental Ancestry Group - genetics Blood Glucose - metabolism Body mass Body mass index Body size Case-Control Studies China Chromosomes Community-Based Participatory Research - methods Control Diabetes Diabetes and Endocrinology/Type 2 Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Endocrinology Fasting Fasting - blood Female Gene Frequency Gene loci Genetic aspects Genetic Predisposition to Disease - genetics Genetic research Genetics Genetics and Genomics/Population Genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Genomics Genotype Glucose Health sciences Homeostasis Hospitals Humans Insulin resistance KCNQ1 protein Laboratories Male Medicine Metabolic disorders Middle Aged Pathogenesis Polymorphism, Single Nucleotide Population Potassium channels (voltage-gated) Prospective Studies Public Health and Epidemiology/Epidemiology Risk analysis Risk Assessment Risk Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Studies
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