TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells

Immune dysregulation in HIV-1 infection is associated with increased expression of inhibitory molecules such as CTLA-4, TGF-beta, and IL-10. In this study we examined one potential mechanism for regulating TGF-beta and IL-10 expression by HIV-specific suppressor CD8+ T cells. No overlap between TGF-...

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Veröffentlicht in:	PloS one 2009-12, Vol.4 (12), p.e8194-e8194
Hauptverfasser:	Elrefaei, Mohamed, Burke, Candace M, Baker, Chris A R, Jones, Norman G, Bousheri, Stephanie, Bangsberg, David R, Cao, Huyen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Antigens Antigens, CD - immunology CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cell cycle Cell growth CTLA-4 Antigen CTLA-4 protein Cytokines Cytotoxicity Foxp3 protein Growth factors HIV HIV-1 - immunology Human immunodeficiency virus Humans Immunoglobulins Immunology/Immune Response Immunology/Immunity to Infections Immunophenotyping Infections Infectious Diseases/HIV Infection and AIDS Interferon Interferon-gamma - biosynthesis Interleukin 10 Interleukin-10 - biosynthesis Lymphocytes Lymphocytes T Peptides Public health Receptors, Transforming Growth Factor beta Signal Transduction - immunology Signaling Species Specificity T cell receptors Transforming Growth Factor beta - biosynthesis γ-Interferon
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