Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor

Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkp...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13123-e13123
Hauptverfasser:	Massey, Andrew J, Borgognoni, Jenifer, Bentley, Carol, Foloppe, Nicolas, Fiumana, Andrea, Walmsley, Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurora B protein Aurora Kinase B Aurora Kinases Biochemistry/Drug Discovery Cancer therapies Cell Biology/Cell Growth and Division Cell Biology/Cell Signaling Cell Cycle Cell death Cell Death - drug effects Checkpoint Kinase 1 Checkpoint Kinase 2 Chemical Biology Chemotherapy CHK1 protein CHK2 protein Chromosomes Crystal structure Crystallography, X-Ray Cytotoxicity Damage detection Deoxyribonucleic acid Development and progression DNA DNA Damage DNA repair Drugs Enzyme inhibitors Flow Cytometry Histone H3 HT29 Cells Humans Inhibition Inhibitors Ionizing radiation Kinases Mitosis Models, Molecular Mortality Oncology/Oncology Agents Ovarian cancer p53 Protein Phosphorylation Phosphotransferases Protein Kinase Inhibitors - pharmacology Protein Kinases - drug effects Protein Kinases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Screening Tumor proteins
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