Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites

Hypersensitivity reactions against nonsteroidal antiinflammatory drugs (NSAIDs) like diclofenac (DF) can manifest as Type I-like allergic reactions including systemic anaphylaxis. However, except for isolated case studies experimental evidence for an IgE-mediated pathomechanism of DF hypersensitivit...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13707
Hauptverfasser:	Harrer, Andrea, Lang, Roland, Grims, Robert, Braitsch, Michaela, Hawranek, Thomas, Aberer, Werner, Vogel, Lothar, Schmid, Walther, Ferreira, Fatima, Himly, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic reactions Allergy Analysis Anaphylaxis Anemia Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antibodies Antibodies - immunology Antigen-antibody reactions Basophils - immunology Biochemistry Biological activity Biological products Blood Carriers Case studies Conjugates Crosslinking Cytochrome Dermatology Diclofenac Diclofenac - adverse effects Drug dosages Drug Hypersensitivity - immunology Effector cells Enzyme-Linked Immunosorbent Assay Ethics Experiments Female Haptens Humans Hypersensitivity Immunization Immunoglobulin E Immunoglobulin E - immunology Immunoglobulin G Immunoglobulins Immunology Immunology/Allergy and Hypersensitivity Mass spectrometry Metabolism Metabolites Mice Mice, Inbred BALB C Molecular biology Nonsteroidal anti-inflammatory agents Nonsteroidal anti-inflammatory drugs Organic chemistry Patients Pharmacology/Adverse Reactions Proteins Scientific imaging
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