Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by motor neuron degeneration. How this disease affects the central motor network is largely unknown. Here, we combined for the first time structural and functional imaging measures on the motor network in patients with...
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| creator | Verstraete, Esther van den Heuvel, Martijn P Veldink, Jan H Blanken, Niels Mandl, René C Hulshoff Pol, Hilleke E van den Berg, Leonard H |
| description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by motor neuron degeneration. How this disease affects the central motor network is largely unknown. Here, we combined for the first time structural and functional imaging measures on the motor network in patients with ALS and healthy controls.
Structural measures included whole brain cortical thickness and diffusion tensor imaging (DTI) of crucial motor tracts. These structural measures were combined with functional connectivity analysis of the motor network based on resting state fMRI. Focal cortical thinning was observed in the primary motor area in patients with ALS compared to controls and was found to correlate with disease progression. DTI revealed reduced FA values in the corpus callosum and in the rostral part of the corticospinal tract. Overall functional organisation of the motor network was unchanged in patients with ALS compared to healthy controls, however the level of functional connectedness was significantly correlated with disease progression rate. Patients with increased connectedness appear to have a more progressive disease course.
We demonstrate structural motor network deterioration in ALS with preserved functional connectivity measures. The positive correlation between functional connectedness of the motor network and disease progression rate could suggest spread of disease along functional connections of the motor network. |
| doi_str_mv | 10.1371/journal.pone.0013664 |
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Structural measures included whole brain cortical thickness and diffusion tensor imaging (DTI) of crucial motor tracts. These structural measures were combined with functional connectivity analysis of the motor network based on resting state fMRI. Focal cortical thinning was observed in the primary motor area in patients with ALS compared to controls and was found to correlate with disease progression. DTI revealed reduced FA values in the corpus callosum and in the rostral part of the corticospinal tract. Overall functional organisation of the motor network was unchanged in patients with ALS compared to healthy controls, however the level of functional connectedness was significantly correlated with disease progression rate. Patients with increased connectedness appear to have a more progressive disease course.
We demonstrate structural motor network deterioration in ALS with preserved functional connectivity measures. The positive correlation between functional connectedness of the motor network and disease progression rate could suggest spread of disease along functional connections of the motor network.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0013664</identifier><identifier>PMID: 21060689</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - pathology ; Anisotropy ; Brain ; Brain - pathology ; Brain mapping ; Case-Control Studies ; Comparative analysis ; Connectivity analysis ; Corpus callosum ; Correlation analysis ; Cortex ; Degeneration ; Development and progression ; Disease ; Disease control ; Disease Progression ; Disease transmission ; Female ; Functional magnetic resonance imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Medical prognosis ; Middle Aged ; Motor Neurons - pathology ; Nervous system diseases ; Neural networks ; Neurodegeneration ; Neuroimaging ; Neurological Disorders/Neuroimaging ; Neurological Disorders/Neuromuscular Diseases ; Neurology ; Neurons ; Neuroscience/Motor Systems ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Patients ; Physiological aspects ; Psychiatry ; Pyramidal tracts ; Radiology and Medical Imaging/Magnetic Resonance Imaging ; Structure-function relationships ; Studies</subject><ispartof>PloS one, 2010-10, Vol.5 (10), p.e13664-e13664</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Verstraete et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Verstraete et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c789t-528d903d7a22f35b2c09d7c807ba9247eb6455e4bf6bd5c8e5b6a7d858ba8e1a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965124/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965124/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21060689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhan, Wang</contributor><creatorcontrib>Verstraete, Esther</creatorcontrib><creatorcontrib>van den Heuvel, Martijn P</creatorcontrib><creatorcontrib>Veldink, Jan H</creatorcontrib><creatorcontrib>Blanken, Niels</creatorcontrib><creatorcontrib>Mandl, René C</creatorcontrib><creatorcontrib>Hulshoff Pol, Hilleke E</creatorcontrib><creatorcontrib>van den Berg, Leonard H</creatorcontrib><title>Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by motor neuron degeneration. How this disease affects the central motor network is largely unknown. Here, we combined for the first time structural and functional imaging measures on the motor network in patients with ALS and healthy controls.
Structural measures included whole brain cortical thickness and diffusion tensor imaging (DTI) of crucial motor tracts. These structural measures were combined with functional connectivity analysis of the motor network based on resting state fMRI. Focal cortical thinning was observed in the primary motor area in patients with ALS compared to controls and was found to correlate with disease progression. DTI revealed reduced FA values in the corpus callosum and in the rostral part of the corticospinal tract. Overall functional organisation of the motor network was unchanged in patients with ALS compared to healthy controls, however the level of functional connectedness was significantly correlated with disease progression rate. Patients with increased connectedness appear to have a more progressive disease course.
We demonstrate structural motor network deterioration in ALS with preserved functional connectivity measures. The positive correlation between functional connectedness of the motor network and disease progression rate could suggest spread of disease along functional connections of the motor network.</description><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Anisotropy</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain mapping</subject><subject>Case-Control Studies</subject><subject>Comparative analysis</subject><subject>Connectivity analysis</subject><subject>Corpus callosum</subject><subject>Correlation analysis</subject><subject>Cortex</subject><subject>Degeneration</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Disease control</subject><subject>Disease Progression</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Motor Neurons - pathology</subject><subject>Nervous system diseases</subject><subject>Neural networks</subject><subject>Neurodegeneration</subject><subject>Neuroimaging</subject><subject>Neurological Disorders/Neuroimaging</subject><subject>Neurological Disorders/Neuromuscular Diseases</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neuroscience/Motor Systems</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Pyramidal tracts</subject><subject>Radiology and Medical Imaging/Magnetic Resonance Imaging</subject><subject>Structure-function relationships</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1trFDEYhgdRbF39B6IDguLFrjln4oVQioeFSsHTbchkMrtpZ5NtkqnuvzfjTsuOFJS5yOTL874h36EonkKwgJjDNxe-D051i613ZgEAxIyRe8UxFBjNGQL4_sH_UfEoxgsAKK4Ye1gcIQgYYJU4Li4_--RD6Uz66cNl2ZiVcSaoZL0rrSvVZudT8Nu11WWnUj7pyqg7E3y08W2pyphCr1M_xJVryrZ3etDmrfbOmby5tmmXsb7ZPS4etKqL5sm4zorvH95_O_00Pzv_uDw9OZtrXok0p6hqBMANVwi1mNZIA9FwXQFeK4EINzUjlBpSt6xuqK4MrZniTUWrWlUGKjwrnu99t52PcsxTlBAJBAXljGViuScary7kNtiNCjvplZV_Aj6spArJ5odKgRnK9lkHIaFVKzCEWCMCuFa4JsNt78bb-npjGm1cytmYmE5PnF3Llb-WSDAKEckGr0aD4K96E5Pc2KhN1ylnfB-loIQKhon4J8kZRpQNvTArXvxF3p2GkVqp_FLr2lxrpQdPeUI4rsjAZmpxB5W_xmxsrrJpbY5PBK8ngswk8yutVB-jXH798v_s-Y8p-_KAXRvVpXX0XT80XJyCZA_q3KcxmPa2GhDIYXhusiGH4ZHj8GTZs8NK3opupgX_BqYDFXk</recordid><startdate>20101027</startdate><enddate>20101027</enddate><creator>Verstraete, Esther</creator><creator>van den Heuvel, Martijn P</creator><creator>Veldink, Jan H</creator><creator>Blanken, Niels</creator><creator>Mandl, René C</creator><creator>Hulshoff Pol, Hilleke E</creator><creator>van den Berg, Leonard H</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20101027</creationdate><title>Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study</title><author>Verstraete, Esther ; van den Heuvel, Martijn P ; Veldink, Jan H ; Blanken, Niels ; Mandl, René C ; Hulshoff Pol, Hilleke E ; van den Berg, Leonard H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c789t-528d903d7a22f35b2c09d7c807ba9247eb6455e4bf6bd5c8e5b6a7d858ba8e1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Anisotropy</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain mapping</topic><topic>Case-Control Studies</topic><topic>Comparative analysis</topic><topic>Connectivity analysis</topic><topic>Corpus callosum</topic><topic>Correlation analysis</topic><topic>Cortex</topic><topic>Degeneration</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Disease control</topic><topic>Disease Progression</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Motor Neurons - pathology</topic><topic>Nervous system diseases</topic><topic>Neural networks</topic><topic>Neurodegeneration</topic><topic>Neuroimaging</topic><topic>Neurological Disorders/Neuroimaging</topic><topic>Neurological Disorders/Neuromuscular Diseases</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neuroscience/Motor Systems</topic><topic>Neurosciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Pyramidal tracts</topic><topic>Radiology and Medical Imaging/Magnetic Resonance Imaging</topic><topic>Structure-function relationships</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verstraete, Esther</creatorcontrib><creatorcontrib>van den Heuvel, Martijn P</creatorcontrib><creatorcontrib>Veldink, Jan H</creatorcontrib><creatorcontrib>Blanken, Niels</creatorcontrib><creatorcontrib>Mandl, René C</creatorcontrib><creatorcontrib>Hulshoff Pol, Hilleke E</creatorcontrib><creatorcontrib>van den Berg, Leonard H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verstraete, Esther</au><au>van den Heuvel, Martijn P</au><au>Veldink, Jan H</au><au>Blanken, Niels</au><au>Mandl, René C</au><au>Hulshoff Pol, Hilleke E</au><au>van den Berg, Leonard H</au><au>Zhan, Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-10-27</date><risdate>2010</risdate><volume>5</volume><issue>10</issue><spage>e13664</spage><epage>e13664</epage><pages>e13664-e13664</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by motor neuron degeneration. How this disease affects the central motor network is largely unknown. Here, we combined for the first time structural and functional imaging measures on the motor network in patients with ALS and healthy controls.
Structural measures included whole brain cortical thickness and diffusion tensor imaging (DTI) of crucial motor tracts. These structural measures were combined with functional connectivity analysis of the motor network based on resting state fMRI. Focal cortical thinning was observed in the primary motor area in patients with ALS compared to controls and was found to correlate with disease progression. DTI revealed reduced FA values in the corpus callosum and in the rostral part of the corticospinal tract. Overall functional organisation of the motor network was unchanged in patients with ALS compared to healthy controls, however the level of functional connectedness was significantly correlated with disease progression rate. Patients with increased connectedness appear to have a more progressive disease course.
We demonstrate structural motor network deterioration in ALS with preserved functional connectivity measures. The positive correlation between functional connectedness of the motor network and disease progression rate could suggest spread of disease along functional connections of the motor network.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21060689</pmid><doi>10.1371/journal.pone.0013664</doi><tpages>e13664</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Anisotropy Brain Brain - pathology Brain mapping Case-Control Studies Comparative analysis Connectivity analysis Corpus callosum Correlation analysis Cortex Degeneration Development and progression Disease Disease control Disease Progression Disease transmission Female Functional magnetic resonance imaging Humans Magnetic Resonance Imaging Male Medical prognosis Middle Aged Motor Neurons - pathology Nervous system diseases Neural networks Neurodegeneration Neuroimaging Neurological Disorders/Neuroimaging Neurological Disorders/Neuromuscular Diseases Neurology Neurons Neuroscience/Motor Systems Neurosciences NMR Nuclear magnetic resonance Patients Physiological aspects Psychiatry Pyramidal tracts Radiology and Medical Imaging/Magnetic Resonance Imaging Structure-function relationships Studies |
| title | Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study |
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