Analysis of chaperone mRNA expression in the adult mouse brain by meta analysis of the Allen Brain Atlas

The pathology of many neurodegenerative diseases is characterized by the accumulation of misfolded and aggregated proteins in various cell types and regional substructures throughout the central and peripheral nervous systems. The accumulation of these aggregated proteins signals dysfunction of cell...

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Veröffentlicht in:	PloS one 2010-10, Vol.5 (10), p.e13675
Hauptverfasser:	Tebbenkamp, Andrew T N, Borchelt, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alzheimer's disease Animal models Animals Atlases as Topic Biosynthesis Brain Brain - metabolism Cell Biology/Cellular Death and Stress Responses Cell Biology/Gene Expression Cell growth Cellular proteins Gene expression Gene Expression Profiling Genes Heat shock proteins Male Messenger RNA Meta-analysis Mice Mice, Inbred C57BL Molecular Chaperones - genetics Molecular Chaperones - metabolism Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurological diseases Neurological Disorders Neurons Neuroscience/Neurobiology of Disease and Regeneration Neurosciences Pathology Phagocytosis Proteasomes Protein folding Proteins RNA, Messenger - genetics Studies Subcellular Fractions - metabolism Substructures Tissues Transcription Transcription (Genetics) Ubiquitin
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