Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome

Toxic shock syndrome (TSS) caused by the superantigen exotoxins of Staphylococcus aureus and Streptococcus pyogenes is characterized by robust T cell activation, profound elevation in systemic levels of multiple cytokines, including interferon-γ (IFN-γ), followed by multiple organ dysfunction and of...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16764
Hauptverfasser:	Tilahun, Ashenafi Y, Holz, Marah, Wu, Tsung-Teh, David, Chella S, Rajagopalan, Govindarajan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Antibodies, Neutralizing - pharmacology Antiinflammatory agents Apoptosis Bacteria Biocompatibility Biology CD4 antigen CD8 antigen Cell activation chemokine KC Chemokines Chemokines - metabolism Cytokines Cytokines - metabolism Digestive tract Disease Progression Disruption Enterotoxins - toxicity Eotaxin Exotoxins gamma -Interferon Genetic engineering Histocompatibility antigen HLA HLA-DR3 Antigen - genetics Homeostasis Immunologic factors Immunology Immunopathogenesis Inflammation Inflammatory bowel disease Inflammatory diseases Interferon Interferon gamma Interferon-gamma - antagonists & inhibitors Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - physiology Interleukin 10 Interleukin 12 Interleukin 17 Interleukin 4 Intestinal Diseases - complications Intestinal Diseases - genetics Intestinal Diseases - mortality Intestinal Diseases - pathology Intestine Laboratories Lethality Liver Lung Lungs Lymphocyte Activation - drug effects Lymphocyte Activation - physiology Lymphocytes Lymphocytes T Macromolecules Medicine Menstruation Mice Mice, Inbred C57BL Mice, Transgenic Monocyte chemoattractant protein 1 Mortality Multiple organ dysfunction syndrome Neutralization Organs Pathogenesis Pathology Permeability Physiological aspects RANTES Rodents Sepsis Shock, Septic - chemically induced Shock, Septic - etiology Shock, Septic - genetics Shock, Septic - mortality Small intestine Spleen Staphylococcus aureus Streptococcus pyogenes Superantigens Superantigens - toxicity T cell receptors T cells T-cell receptor Toxic shock syndrome Transgenic animals Transgenic mice γ-Interferon
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