Sexually transmitted infections among HIV-1-discordant couples
More new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large proportion of new HIV-1 infections. Understanding correlates of STIs am...
Gespeichert in:
| Veröffentlicht in: | PloS one 2009-12, Vol.4 (12), p.e8276-e8276 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e8276 |
|---|---|
| container_issue | 12 |
| container_start_page | e8276 |
| container_title | PloS one |
| container_volume | 4 |
| creator | Guthrie, Brandon L Kiarie, James N Morrison, Susan John-Stewart, Grace C Kinuthia, John Whittington, William L H Farquhar, Carey |
| description | More new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large proportion of new HIV-1 infections. Understanding correlates of STIs among discordant couples will aid in optimizing interventions to prevent HIV-1 transmission in these couples.
HIV-1-discordant couples in which HIV-1-infected partners were HSV-2-seropositive were tested for syphilis, chlamydia, gonorrhea, and trichomoniasis, and HIV-1-uninfected partners were tested for HSV-2. We assessed sociodemographic, behavioral, and biological correlates of a current STI.
Of 416 couples enrolled, 16% were affected by a treatable STI, and among these both partners were infected in 17% of couples. A treatable STI was found in 46 (11%) females and 30 (7%) males. The most prevalent infections were trichomoniasis (5.9%) and syphilis (2.6%). Participants were 5.9-fold more likely to have an STI if their partner had an STI (P |
| doi_str_mv | 10.1371/journal.pone.0008276 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1292192239</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A472770316</galeid><doaj_id>oai_doaj_org_article_167e98bfc0bd4f278ea8fe1909cad412</doaj_id><sourcerecordid>A472770316</sourcerecordid><originalsourceid>FETCH-LOGICAL-c726t-4684a635234ca9bfc44fec54d8aa9aca72ab2dd558ce6e492289ae45f13a41bd3</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbK3-A9EFoeLFrPmaZHJTKEXtQqFgtbfhbJLZnSUzWScZaf-9p91t2RWRkouE5Dlvcs6bUxRvKZlSrujnVRyHHsJ0HXs_JYTUTMlnxSHVnJWSEf58Z31QvEppRUjFaylfFgeMEEorLQ-Lkyt_M0IIt5M8QJ-6NmfvJm3feJvb2KcJdLFfTM5n1yUtXZtsHBz0eWLjuA4-vS5eNBCSf7Odj4qfX7_8ODsvLy6_zc5OL0qrmMylkLUAySvGhQU9b6wQeEElXA2gwYJiMGfOVVVtvfRCM1Zr8KJqKAdB544fFe83uusQk9mmngxlmlGkuUZitiFchJVZD20Hw62J0Jr7jTgsDAy5tcEbKpXXNb6CzJ1omKo91I2nmmgLTlCGWifb28Z55531PRYn7Inun_Tt0izib4NaNWMCBT5uBYb4a_Qpmw5L50OA3scxGSUkOlCRJ5AcvRZcciSP_0syKiSXTCH44S_w3_WabqgFYEnQ8IiZWBzOd63FP9W0uH8qFFOKcCox4NNeADLZ3-QFjCmZ2dX3p7OX1_vs8Q679BDyMsUw3n-_fVBsQDvElAbfPBpCiblriYc8zV1LmG1LYNi7XTMfgx56gP8BPwoGnw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1292192239</pqid></control><display><type>article</type><title>Sexually transmitted infections among HIV-1-discordant couples</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Guthrie, Brandon L ; Kiarie, James N ; Morrison, Susan ; John-Stewart, Grace C ; Kinuthia, John ; Whittington, William L H ; Farquhar, Carey</creator><contributor>Joly, Etienne</contributor><creatorcontrib>Guthrie, Brandon L ; Kiarie, James N ; Morrison, Susan ; John-Stewart, Grace C ; Kinuthia, John ; Whittington, William L H ; Farquhar, Carey ; Joly, Etienne</creatorcontrib><description>More new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large proportion of new HIV-1 infections. Understanding correlates of STIs among discordant couples will aid in optimizing interventions to prevent HIV-1 transmission in these couples.
HIV-1-discordant couples in which HIV-1-infected partners were HSV-2-seropositive were tested for syphilis, chlamydia, gonorrhea, and trichomoniasis, and HIV-1-uninfected partners were tested for HSV-2. We assessed sociodemographic, behavioral, and biological correlates of a current STI.
Of 416 couples enrolled, 16% were affected by a treatable STI, and among these both partners were infected in 17% of couples. A treatable STI was found in 46 (11%) females and 30 (7%) males. The most prevalent infections were trichomoniasis (5.9%) and syphilis (2.6%). Participants were 5.9-fold more likely to have an STI if their partner had an STI (P<0.01), and STIs were more common among those reporting any unprotected sex (OR = 2.43; P<0.01) and those with low education (OR = 3.00; P<0.01). Among HIV-1-uninfected participants with an HSV-2-seropositive partner, females were significantly more likely to be HSV-2-seropositive than males (78% versus 50%, P<0.01).
Treatable STIs were common among HIV-1-discordant couples and the majority of couples affected by an STI were discordant for the STI, with relatively high HSV-2 discordance. Awareness of STI correlates and treatment of both partners may reduce HIV-1 transmission.
ClinicalTrials.gov NCT00194519.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0008276</identifier><identifier>PMID: 20011596</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Biological effects ; Chlamydia ; Correlation ; Counseling ; Couples ; Demography ; Discordance ; Disease transmission ; Epidemics ; Epidemiology ; Female ; Females ; Gonorrhea ; Gynecology ; Health aspects ; Health risks ; Herpes viruses ; Herpesvirus 2, Human - physiology ; HIV ; HIV Infections - complications ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - physiology ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Humans ; Husband-wife relations ; Infections ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/HIV Infection and AIDS ; Infectious Diseases/Sexually Transmitted Diseases ; Laboratories ; Male ; Males ; Medicine ; Mens health ; Obstetrics ; Prevalence ; Prevention ; Public Health and Epidemiology/Epidemiology ; Public Health and Epidemiology/Infectious Diseases ; Sexual Behavior ; Sexual Partners ; Sexually transmitted disease prevention ; Sexually transmitted diseases ; Sexually Transmitted Diseases - complications ; Sexually Transmitted Diseases - epidemiology ; STD ; Syphilis ; Treponema pallidum ; Trichomoniasis</subject><ispartof>PloS one, 2009-12, Vol.4 (12), p.e8276-e8276</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Guthrie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Guthrie et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-4684a635234ca9bfc44fec54d8aa9aca72ab2dd558ce6e492289ae45f13a41bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788224/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788224/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20011596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Joly, Etienne</contributor><creatorcontrib>Guthrie, Brandon L</creatorcontrib><creatorcontrib>Kiarie, James N</creatorcontrib><creatorcontrib>Morrison, Susan</creatorcontrib><creatorcontrib>John-Stewart, Grace C</creatorcontrib><creatorcontrib>Kinuthia, John</creatorcontrib><creatorcontrib>Whittington, William L H</creatorcontrib><creatorcontrib>Farquhar, Carey</creatorcontrib><title>Sexually transmitted infections among HIV-1-discordant couples</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>More new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large proportion of new HIV-1 infections. Understanding correlates of STIs among discordant couples will aid in optimizing interventions to prevent HIV-1 transmission in these couples.
HIV-1-discordant couples in which HIV-1-infected partners were HSV-2-seropositive were tested for syphilis, chlamydia, gonorrhea, and trichomoniasis, and HIV-1-uninfected partners were tested for HSV-2. We assessed sociodemographic, behavioral, and biological correlates of a current STI.
Of 416 couples enrolled, 16% were affected by a treatable STI, and among these both partners were infected in 17% of couples. A treatable STI was found in 46 (11%) females and 30 (7%) males. The most prevalent infections were trichomoniasis (5.9%) and syphilis (2.6%). Participants were 5.9-fold more likely to have an STI if their partner had an STI (P<0.01), and STIs were more common among those reporting any unprotected sex (OR = 2.43; P<0.01) and those with low education (OR = 3.00; P<0.01). Among HIV-1-uninfected participants with an HSV-2-seropositive partner, females were significantly more likely to be HSV-2-seropositive than males (78% versus 50%, P<0.01).
Treatable STIs were common among HIV-1-discordant couples and the majority of couples affected by an STI were discordant for the STI, with relatively high HSV-2 discordance. Awareness of STI correlates and treatment of both partners may reduce HIV-1 transmission.
ClinicalTrials.gov NCT00194519.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Biological effects</subject><subject>Chlamydia</subject><subject>Correlation</subject><subject>Counseling</subject><subject>Couples</subject><subject>Demography</subject><subject>Discordance</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Females</subject><subject>Gonorrhea</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Herpes viruses</subject><subject>Herpesvirus 2, Human - physiology</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Husband-wife relations</subject><subject>Infections</subject><subject>Infectious Diseases/Epidemiology and Control of Infectious Diseases</subject><subject>Infectious Diseases/HIV Infection and AIDS</subject><subject>Infectious Diseases/Sexually Transmitted Diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Males</subject><subject>Medicine</subject><subject>Mens health</subject><subject>Obstetrics</subject><subject>Prevalence</subject><subject>Prevention</subject><subject>Public Health and Epidemiology/Epidemiology</subject><subject>Public Health and Epidemiology/Infectious Diseases</subject><subject>Sexual Behavior</subject><subject>Sexual Partners</subject><subject>Sexually transmitted disease prevention</subject><subject>Sexually transmitted diseases</subject><subject>Sexually Transmitted Diseases - complications</subject><subject>Sexually Transmitted Diseases - epidemiology</subject><subject>STD</subject><subject>Syphilis</subject><subject>Treponema pallidum</subject><subject>Trichomoniasis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9EFoeLFrPmaZHJTKEXtQqFgtbfhbJLZnSUzWScZaf-9p91t2RWRkouE5Dlvcs6bUxRvKZlSrujnVRyHHsJ0HXs_JYTUTMlnxSHVnJWSEf58Z31QvEppRUjFaylfFgeMEEorLQ-Lkyt_M0IIt5M8QJ-6NmfvJm3feJvb2KcJdLFfTM5n1yUtXZtsHBz0eWLjuA4-vS5eNBCSf7Odj4qfX7_8ODsvLy6_zc5OL0qrmMylkLUAySvGhQU9b6wQeEElXA2gwYJiMGfOVVVtvfRCM1Zr8KJqKAdB544fFe83uusQk9mmngxlmlGkuUZitiFchJVZD20Hw62J0Jr7jTgsDAy5tcEbKpXXNb6CzJ1omKo91I2nmmgLTlCGWifb28Z55531PRYn7Inun_Tt0izib4NaNWMCBT5uBYb4a_Qpmw5L50OA3scxGSUkOlCRJ5AcvRZcciSP_0syKiSXTCH44S_w3_WabqgFYEnQ8IiZWBzOd63FP9W0uH8qFFOKcCox4NNeADLZ3-QFjCmZ2dX3p7OX1_vs8Q679BDyMsUw3n-_fVBsQDvElAbfPBpCiblriYc8zV1LmG1LYNi7XTMfgx56gP8BPwoGnw</recordid><startdate>20091214</startdate><enddate>20091214</enddate><creator>Guthrie, Brandon L</creator><creator>Kiarie, James N</creator><creator>Morrison, Susan</creator><creator>John-Stewart, Grace C</creator><creator>Kinuthia, John</creator><creator>Whittington, William L H</creator><creator>Farquhar, Carey</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20091214</creationdate><title>Sexually transmitted infections among HIV-1-discordant couples</title><author>Guthrie, Brandon L ; Kiarie, James N ; Morrison, Susan ; John-Stewart, Grace C ; Kinuthia, John ; Whittington, William L H ; Farquhar, Carey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c726t-4684a635234ca9bfc44fec54d8aa9aca72ab2dd558ce6e492289ae45f13a41bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>Biological effects</topic><topic>Chlamydia</topic><topic>Correlation</topic><topic>Counseling</topic><topic>Couples</topic><topic>Demography</topic><topic>Discordance</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Females</topic><topic>Gonorrhea</topic><topic>Gynecology</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Herpes viruses</topic><topic>Herpesvirus 2, Human - physiology</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Husband-wife relations</topic><topic>Infections</topic><topic>Infectious Diseases/Epidemiology and Control of Infectious Diseases</topic><topic>Infectious Diseases/HIV Infection and AIDS</topic><topic>Infectious Diseases/Sexually Transmitted Diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Males</topic><topic>Medicine</topic><topic>Mens health</topic><topic>Obstetrics</topic><topic>Prevalence</topic><topic>Prevention</topic><topic>Public Health and Epidemiology/Epidemiology</topic><topic>Public Health and Epidemiology/Infectious Diseases</topic><topic>Sexual Behavior</topic><topic>Sexual Partners</topic><topic>Sexually transmitted disease prevention</topic><topic>Sexually transmitted diseases</topic><topic>Sexually Transmitted Diseases - complications</topic><topic>Sexually Transmitted Diseases - epidemiology</topic><topic>STD</topic><topic>Syphilis</topic><topic>Treponema pallidum</topic><topic>Trichomoniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guthrie, Brandon L</creatorcontrib><creatorcontrib>Kiarie, James N</creatorcontrib><creatorcontrib>Morrison, Susan</creatorcontrib><creatorcontrib>John-Stewart, Grace C</creatorcontrib><creatorcontrib>Kinuthia, John</creatorcontrib><creatorcontrib>Whittington, William L H</creatorcontrib><creatorcontrib>Farquhar, Carey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guthrie, Brandon L</au><au>Kiarie, James N</au><au>Morrison, Susan</au><au>John-Stewart, Grace C</au><au>Kinuthia, John</au><au>Whittington, William L H</au><au>Farquhar, Carey</au><au>Joly, Etienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexually transmitted infections among HIV-1-discordant couples</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-12-14</date><risdate>2009</risdate><volume>4</volume><issue>12</issue><spage>e8276</spage><epage>e8276</epage><pages>e8276-e8276</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>More new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large proportion of new HIV-1 infections. Understanding correlates of STIs among discordant couples will aid in optimizing interventions to prevent HIV-1 transmission in these couples.
HIV-1-discordant couples in which HIV-1-infected partners were HSV-2-seropositive were tested for syphilis, chlamydia, gonorrhea, and trichomoniasis, and HIV-1-uninfected partners were tested for HSV-2. We assessed sociodemographic, behavioral, and biological correlates of a current STI.
Of 416 couples enrolled, 16% were affected by a treatable STI, and among these both partners were infected in 17% of couples. A treatable STI was found in 46 (11%) females and 30 (7%) males. The most prevalent infections were trichomoniasis (5.9%) and syphilis (2.6%). Participants were 5.9-fold more likely to have an STI if their partner had an STI (P<0.01), and STIs were more common among those reporting any unprotected sex (OR = 2.43; P<0.01) and those with low education (OR = 3.00; P<0.01). Among HIV-1-uninfected participants with an HSV-2-seropositive partner, females were significantly more likely to be HSV-2-seropositive than males (78% versus 50%, P<0.01).
Treatable STIs were common among HIV-1-discordant couples and the majority of couples affected by an STI were discordant for the STI, with relatively high HSV-2 discordance. Awareness of STI correlates and treatment of both partners may reduce HIV-1 transmission.
ClinicalTrials.gov NCT00194519.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20011596</pmid><doi>10.1371/journal.pone.0008276</doi><tpages>e8276</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2009-12, Vol.4 (12), p.e8276-e8276 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1292192239 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acquired immune deficiency syndrome Adult AIDS Biological effects Chlamydia Correlation Counseling Couples Demography Discordance Disease transmission Epidemics Epidemiology Female Females Gonorrhea Gynecology Health aspects Health risks Herpes viruses Herpesvirus 2, Human - physiology HIV HIV Infections - complications HIV Infections - transmission HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Husband-wife relations Infections Infectious Diseases/Epidemiology and Control of Infectious Diseases Infectious Diseases/HIV Infection and AIDS Infectious Diseases/Sexually Transmitted Diseases Laboratories Male Males Medicine Mens health Obstetrics Prevalence Prevention Public Health and Epidemiology/Epidemiology Public Health and Epidemiology/Infectious Diseases Sexual Behavior Sexual Partners Sexually transmitted disease prevention Sexually transmitted diseases Sexually Transmitted Diseases - complications Sexually Transmitted Diseases - epidemiology STD Syphilis Treponema pallidum Trichomoniasis |
| title | Sexually transmitted infections among HIV-1-discordant couples |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T19%3A36%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sexually%20transmitted%20infections%20among%20HIV-1-discordant%20couples&rft.jtitle=PloS%20one&rft.au=Guthrie,%20Brandon%20L&rft.date=2009-12-14&rft.volume=4&rft.issue=12&rft.spage=e8276&rft.epage=e8276&rft.pages=e8276-e8276&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0008276&rft_dat=%3Cgale_plos_%3EA472770316%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292192239&rft_id=info:pmid/20011596&rft_galeid=A472770316&rft_doaj_id=oai_doaj_org_article_167e98bfc0bd4f278ea8fe1909cad412&rfr_iscdi=true |