Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis

The existence of a hypothalamic gonadotropin-inhibiting system has been elusive. A neuropeptide named gonadotropin-inhibitory hormone (GnIH, SIKPSAYLPLRF-NH(2)) which directly inhibits gonadotropin synthesis and release from the pituitary was recently identified in quail hypothalamus. Here we identi...

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Veröffentlicht in:	PloS one 2009-12, Vol.4 (12), p.e8400-e8400
Hauptverfasser:	Ubuka, Takayoshi, Morgan, Kevin, Pawson, Adam J, Osugi, Tomohiro, Chowdhury, Vishwajit S, Minakata, Hiroyuki, Tsutsui, Kazuyoshi, Millar, Robert P, Bentley, George E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Analysis Biological activity Biology Brain Brain research Calcium mobilization Chromatography Councils Deoxyribonucleic acid Diabetes and Endocrinology/Endocrinology Diabetes and Endocrinology/Neuroendocrinology and Pituitary Diabetes and Endocrinology/Reproductive Endocrinology DNA DNA sequencing Endocrinology Gene expression Gene Expression Regulation Gene sequencing Glycoproteins Glycoproteins - chemistry Gonadotropin-releasing hormone Gonadotropins Gynecology Homology Hormones Humans Hybridization Hypothalamic-pituitary-gonadal axis Hypothalamo-Hypophyseal System - cytology Hypothalamo-Hypophyseal System - metabolism Hypothalamus Hypothalamus (dorsomedial) Identification Immunocytochemistry Inhibition Luteinizing hormone Mammals Mass spectrometry Mass spectroscopy Medical research Molecular Sequence Data Neurons Neurons - cytology Neurons - metabolism Neuropeptides Neuropeptides - chemistry Neuropeptides - metabolism Neurosciences Ovis aries Pituitary Pituitary (anterior) Pituitary-Adrenal System - cytology Pituitary-Adrenal System - metabolism Pituitary-gonadal axis Polymerase chain reaction Polypeptides Preoptic area Purification Receptors, Neuropeptide - genetics Receptors, Neuropeptide - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Scientific imaging Sequence Homology, Amino Acid Sheep Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Studies
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