Spinal cord injury reveals multilineage differentiation of ependymal cells
Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail...
Gespeichert in:
| Veröffentlicht in: | PLoS biology 2008-07, Vol.6 (7), p.e182-e182 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e182 |
|---|---|
| container_issue | 7 |
| container_start_page | e182 |
| container_title | PLoS biology |
| container_volume | 6 |
| creator | Meletis, Konstantinos Barnabé-Heider, Fanie Carlén, Marie Evergren, Emma Tomilin, Nikolay Shupliakov, Oleg Frisén, Jonas |
| description | Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury. |
| doi_str_mv | 10.1371/journal.pbio.0060182 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1292170714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A202126604</galeid><doaj_id>oai_doaj_org_article_12e0b66476344eed8c722adf3eb1708d</doaj_id><sourcerecordid>A202126604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c762t-2ca9ebf4506d2bf506c664f4ef8c50ebd32c43a4acecd00c90e15469a936ffa63</originalsourceid><addsrcrecordid>eNqVk12L1DAUhoso7of-A9GCIHjRMUmTtL1ZWBY_RhYXXPU2pMnJmLFtatLuOv_e1Km6lQWVXCScPO-b5A0nSR5htMJ5gV9s3eg72az62roVQhzhktxJDjGjLCvKkt29sT5IjkLYIkRIRcr7yQEuOcNFlR8mby97G11S5bxObbcd_S71cAWyCWk7NoNtbAdyA6m2xoCHbrBysK5LnUmhh07v2kkNTRMeJPdMlMHDeT5OPr56-eHsTXZ-8Xp9dnqeqYKTISNKVlAbyhDXpDZxUpxTQ8GUiiGodU4UzSWVCpRGSFUI4jt4JaucGyN5fpw82fv2jQtijiEIHN-GC1RgGon1ntBObkXvbSv9TjhpxY-C8xsh_WBVA1EFqI7nFzynFECXqiBEapNDHc1KHb2yvVe4hn6sF25z6UtcgWA8R7yK_Ml8u7FuQauYmJfNQrbc6exnsXFXgtCCMYqjwbPZwLuvI4RBtDZMAcsO3BhEPIOXqKB_BQlGrCJsCuzpH-Dtoc3URsZcbGdcvJ6aLMUpQQQTztFErW6h4tDQWuU6MDbWF4LnC0FkBvg2bOQYglhfvv8P9t2_sxeflizds8q7EDyYX9-BkZia6WcgYmomMTdTlD2--ZW_RXP35N8Bts8aZQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1292170714</pqid></control><display><type>article</type><title>Spinal cord injury reveals multilineage differentiation of ependymal cells</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>Public Library of Science (PLoS)</source><creator>Meletis, Konstantinos ; Barnabé-Heider, Fanie ; Carlén, Marie ; Evergren, Emma ; Tomilin, Nikolay ; Shupliakov, Oleg ; Frisén, Jonas</creator><creatorcontrib>Meletis, Konstantinos ; Barnabé-Heider, Fanie ; Carlén, Marie ; Evergren, Emma ; Tomilin, Nikolay ; Shupliakov, Oleg ; Frisén, Jonas</creatorcontrib><description>Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.</description><identifier>ISSN: 1545-7885</identifier><identifier>ISSN: 1544-9173</identifier><identifier>EISSN: 1545-7885</identifier><identifier>DOI: 10.1371/journal.pbio.0060182</identifier><identifier>PMID: 18651793</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Cell Biology ; Cell Differentiation ; Cell Lineage ; Cell Movement ; Cytoplasm ; Developmental Biology ; Ependyma - pathology ; Medical research ; Mice ; Neuroglia - pathology ; Neurons - pathology ; Neurons - physiology ; Neuroscience ; Population ; Rodents ; Spinal cord injuries ; Spinal Cord Injuries - pathology ; Stem cells ; Stem Cells - pathology ; Stem Cells - physiology</subject><ispartof>PLoS biology, 2008-07, Vol.6 (7), p.e182-e182</ispartof><rights>COPYRIGHT 2008 Public Library of Science</rights><rights>2008 Meletis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Meletis K, Barnabé-Heider F, Carlén M, Evergren E, Tomilin N, et al. (2008) Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells. PLoS Biol 6(7): e182. doi:10.1371/journal.pbio.0060182</rights><rights>2008 Meletis et al. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c762t-2ca9ebf4506d2bf506c664f4ef8c50ebd32c43a4acecd00c90e15469a936ffa63</citedby><cites>FETCH-LOGICAL-c762t-2ca9ebf4506d2bf506c664f4ef8c50ebd32c43a4acecd00c90e15469a936ffa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475541/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475541/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18651793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:117390626$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Meletis, Konstantinos</creatorcontrib><creatorcontrib>Barnabé-Heider, Fanie</creatorcontrib><creatorcontrib>Carlén, Marie</creatorcontrib><creatorcontrib>Evergren, Emma</creatorcontrib><creatorcontrib>Tomilin, Nikolay</creatorcontrib><creatorcontrib>Shupliakov, Oleg</creatorcontrib><creatorcontrib>Frisén, Jonas</creatorcontrib><title>Spinal cord injury reveals multilineage differentiation of ependymal cells</title><title>PLoS biology</title><addtitle>PLoS Biol</addtitle><description>Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.</description><subject>Animals</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Cell Movement</subject><subject>Cytoplasm</subject><subject>Developmental Biology</subject><subject>Ependyma - pathology</subject><subject>Medical research</subject><subject>Mice</subject><subject>Neuroglia - pathology</subject><subject>Neurons - pathology</subject><subject>Neurons - physiology</subject><subject>Neuroscience</subject><subject>Population</subject><subject>Rodents</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Stem cells</subject><subject>Stem Cells - pathology</subject><subject>Stem Cells - physiology</subject><issn>1545-7885</issn><issn>1544-9173</issn><issn>1545-7885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqVk12L1DAUhoso7of-A9GCIHjRMUmTtL1ZWBY_RhYXXPU2pMnJmLFtatLuOv_e1Km6lQWVXCScPO-b5A0nSR5htMJ5gV9s3eg72az62roVQhzhktxJDjGjLCvKkt29sT5IjkLYIkRIRcr7yQEuOcNFlR8mby97G11S5bxObbcd_S71cAWyCWk7NoNtbAdyA6m2xoCHbrBysK5LnUmhh07v2kkNTRMeJPdMlMHDeT5OPr56-eHsTXZ-8Xp9dnqeqYKTISNKVlAbyhDXpDZxUpxTQ8GUiiGodU4UzSWVCpRGSFUI4jt4JaucGyN5fpw82fv2jQtijiEIHN-GC1RgGon1ntBObkXvbSv9TjhpxY-C8xsh_WBVA1EFqI7nFzynFECXqiBEapNDHc1KHb2yvVe4hn6sF25z6UtcgWA8R7yK_Ml8u7FuQauYmJfNQrbc6exnsXFXgtCCMYqjwbPZwLuvI4RBtDZMAcsO3BhEPIOXqKB_BQlGrCJsCuzpH-Dtoc3URsZcbGdcvJ6aLMUpQQQTztFErW6h4tDQWuU6MDbWF4LnC0FkBvg2bOQYglhfvv8P9t2_sxeflizds8q7EDyYX9-BkZia6WcgYmomMTdTlD2--ZW_RXP35N8Bts8aZQ</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Meletis, Konstantinos</creator><creator>Barnabé-Heider, Fanie</creator><creator>Carlén, Marie</creator><creator>Evergren, Emma</creator><creator>Tomilin, Nikolay</creator><creator>Shupliakov, Oleg</creator><creator>Frisén, Jonas</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><scope>DOA</scope><scope>CZG</scope></search><sort><creationdate>20080701</creationdate><title>Spinal cord injury reveals multilineage differentiation of ependymal cells</title><author>Meletis, Konstantinos ; Barnabé-Heider, Fanie ; Carlén, Marie ; Evergren, Emma ; Tomilin, Nikolay ; Shupliakov, Oleg ; Frisén, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c762t-2ca9ebf4506d2bf506c664f4ef8c50ebd32c43a4acecd00c90e15469a936ffa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Cell Movement</topic><topic>Cytoplasm</topic><topic>Developmental Biology</topic><topic>Ependyma - pathology</topic><topic>Medical research</topic><topic>Mice</topic><topic>Neuroglia - pathology</topic><topic>Neurons - pathology</topic><topic>Neurons - physiology</topic><topic>Neuroscience</topic><topic>Population</topic><topic>Rodents</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Stem cells</topic><topic>Stem Cells - pathology</topic><topic>Stem Cells - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meletis, Konstantinos</creatorcontrib><creatorcontrib>Barnabé-Heider, Fanie</creatorcontrib><creatorcontrib>Carlén, Marie</creatorcontrib><creatorcontrib>Evergren, Emma</creatorcontrib><creatorcontrib>Tomilin, Nikolay</creatorcontrib><creatorcontrib>Shupliakov, Oleg</creatorcontrib><creatorcontrib>Frisén, Jonas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Biology</collection><jtitle>PLoS biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meletis, Konstantinos</au><au>Barnabé-Heider, Fanie</au><au>Carlén, Marie</au><au>Evergren, Emma</au><au>Tomilin, Nikolay</au><au>Shupliakov, Oleg</au><au>Frisén, Jonas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinal cord injury reveals multilineage differentiation of ependymal cells</atitle><jtitle>PLoS biology</jtitle><addtitle>PLoS Biol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>6</volume><issue>7</issue><spage>e182</spage><epage>e182</epage><pages>e182-e182</pages><issn>1545-7885</issn><issn>1544-9173</issn><eissn>1545-7885</eissn><abstract>Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18651793</pmid><doi>10.1371/journal.pbio.0060182</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1545-7885 |
| ispartof | PLoS biology, 2008-07, Vol.6 (7), p.e182-e182 |
| issn | 1545-7885 1544-9173 1545-7885 |
| language | eng |
| recordid | cdi_plos_journals_1292170714 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Public Library of Science (PLoS) |
| subjects | Animals Cell Biology Cell Differentiation Cell Lineage Cell Movement Cytoplasm Developmental Biology Ependyma - pathology Medical research Mice Neuroglia - pathology Neurons - pathology Neurons - physiology Neuroscience Population Rodents Spinal cord injuries Spinal Cord Injuries - pathology Stem cells Stem Cells - pathology Stem Cells - physiology |
| title | Spinal cord injury reveals multilineage differentiation of ependymal cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T12%3A42%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spinal%20cord%20injury%20reveals%20multilineage%20differentiation%20of%20ependymal%20cells&rft.jtitle=PLoS%20biology&rft.au=Meletis,%20Konstantinos&rft.date=2008-07-01&rft.volume=6&rft.issue=7&rft.spage=e182&rft.epage=e182&rft.pages=e182-e182&rft.issn=1545-7885&rft.eissn=1545-7885&rft_id=info:doi/10.1371/journal.pbio.0060182&rft_dat=%3Cgale_plos_%3EA202126604%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1292170714&rft_id=info:pmid/18651793&rft_galeid=A202126604&rft_doaj_id=oai_doaj_org_article_12e0b66476344eed8c722adf3eb1708d&rfr_iscdi=true |