SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments

LITAF is a small cellular protein with an unknown function. The C-terminus of LITAF contains a highly conserved domain termed the SIMPLE-like domain (SLD), while the N-terminus contains two PPXY motifs that mediate protein-protein interactions with WW-domain containing proteins. LITAF also harbors t...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16873
Hauptverfasser:	Eaton, Heather E, Desrochers, Guillaume, Drory, Samuel B, Metcalf, Julie, Angers, Annie, Brunetti, Craig R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Animals, Newborn Biology C-Terminus Cell Compartmentation Cell cycle Cell Line Cell lines Cellular proteins Cercopithecus aethiops Compartments Disruption Enzymes Golgi apparatus Humans Intracellular Ligands Ligases Localization Lysosomes Lysosomes - metabolism Molecular biology Molecular Sequence Data Mutagenesis, Site-Directed N-Terminus Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Protein Binding Protein interaction Protein Interaction Domains and Motifs - genetics Protein Interaction Domains and Motifs - physiology Protein Transport - genetics Protein-protein interactions Proteins Repressor Proteins - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Translocation Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Up-Regulation - physiology
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