Pre-steady-state decoding of the Bicoid morphogen gradient
Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and ti...
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| Veröffentlicht in: | PLoS biology 2007-02, Vol.5 (2), p.e46-e46 |
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| creator | Bergmann, Sven Sandler, Oded Sberro, Hila Shnider, Sara Schejter, Eyal Shilo, Ben-Zion Barkai, Naama |
| description | Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may precede the convergence of the gradient to its steady state. Here we consider the implications of pre-steady-state decoding of the Bicoid morphogen gradient for patterning of the anterior-posterior axis of the Drosophila embryo. Quantitative analysis of the shift in the expression domains of several Bicoid targets (gap genes) upon alteration of bcd dosage, as well as a temporal analysis of a reporter for Bicoid activity, suggest that a transient decoding mechanism is employed in this setting. We show that decoding the pre-steady-state morphogen profile can reduce patterning errors caused by fluctuations in the rate of morphogen production. This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage. |
| doi_str_mv | 10.1371/journal.pbio.0050046 |
| format | Article |
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It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may precede the convergence of the gradient to its steady state. Here we consider the implications of pre-steady-state decoding of the Bicoid morphogen gradient for patterning of the anterior-posterior axis of the Drosophila embryo. Quantitative analysis of the shift in the expression domains of several Bicoid targets (gap genes) upon alteration of bcd dosage, as well as a temporal analysis of a reporter for Bicoid activity, suggest that a transient decoding mechanism is employed in this setting. We show that decoding the pre-steady-state morphogen profile can reduce patterning errors caused by fluctuations in the rate of morphogen production. This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage.</description><identifier>ISSN: 1545-7885</identifier><identifier>ISSN: 1544-9173</identifier><identifier>EISSN: 1545-7885</identifier><identifier>DOI: 10.1371/journal.pbio.0050046</identifier><identifier>PMID: 17298180</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Body Patterning - physiology ; Cell Differentiation - genetics ; Computational Biology ; Developmental Biology ; Drosophila ; Drosophila - embryology ; Drosophila - genetics ; Drosophila - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Drosophila Proteins - physiology ; Embryo, Nonmammalian - cytology ; Embryo, Nonmammalian - metabolism ; Embryonic Development ; Embryos ; Gene expression ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Genetic aspects ; Genetics and Genomics ; GTPase-Activating Proteins - genetics ; GTPase-Activating Proteins - metabolism ; Homeodomain Proteins - metabolism ; Homeodomain Proteins - physiology ; Insects ; Morphogenesis ; Observations ; Signal Transduction ; Studies ; Trans-Activators - metabolism ; Trans-Activators - physiology</subject><ispartof>PLoS biology, 2007-02, Vol.5 (2), p.e46-e46</ispartof><rights>COPYRIGHT 2007 Public Library of Science</rights><rights>2007 Bergmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Bergmann S, Sandler O, Sberro H, Shnider S, Schejter E, et al. (2007) Pre-Steady-State Decoding of the Bicoid Morphogen Gradient. 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It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may precede the convergence of the gradient to its steady state. Here we consider the implications of pre-steady-state decoding of the Bicoid morphogen gradient for patterning of the anterior-posterior axis of the Drosophila embryo. Quantitative analysis of the shift in the expression domains of several Bicoid targets (gap genes) upon alteration of bcd dosage, as well as a temporal analysis of a reporter for Bicoid activity, suggest that a transient decoding mechanism is employed in this setting. We show that decoding the pre-steady-state morphogen profile can reduce patterning errors caused by fluctuations in the rate of morphogen production. This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage.</description><subject>Animals</subject><subject>Body Patterning - physiology</subject><subject>Cell Differentiation - genetics</subject><subject>Computational Biology</subject><subject>Developmental Biology</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Drosophila Proteins - physiology</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Embryonic Development</subject><subject>Embryos</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Reporter</subject><subject>Genetic aspects</subject><subject>Genetics and Genomics</subject><subject>GTPase-Activating Proteins - genetics</subject><subject>GTPase-Activating Proteins - metabolism</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Homeodomain Proteins - physiology</subject><subject>Insects</subject><subject>Morphogenesis</subject><subject>Observations</subject><subject>Signal Transduction</subject><subject>Studies</subject><subject>Trans-Activators - metabolism</subject><subject>Trans-Activators - physiology</subject><issn>1545-7885</issn><issn>1544-9173</issn><issn>1545-7885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVk9uKFDEQhhtR3HX1DUQbBMGLGXPoHNoLYV08DCyueLoN1Ul1T4aezpj0iPv2ZpxWd2RBJRcJla_-qkqliuI-JXPKFX26Cts4QD_fND7MCRGEVPJGcUxFJWZKa3HzyvmouJPSihDGaqZvF0dUsVpTTY6LZ-8iztKI4C7zBiOWDm1wfujK0JbjEssX3gbvynWIm2XocCi7CM7jMN4tbrXQJ7w37SfFp1cvP569mZ1fvF6cnZ7PrGZ8nAEBDdgo0rRoqap0ywXXtW01AKXM1qqqGslEpTgI6zDzHJm0jaulRuD8pHi41930IZmp7GRoroVKTRTNxGJPuAArs4l-DfHSBPDmhyHEzkAcve3R8BzVMiU0tVA5yRqCObKWaJmQiDut51O0bbNGZ3OhEfoD0cObwS9NF74aqmpSC5UFHk8CMXzZYhrN2ieLfQ8Dhm0ysiZE1pr_FaS1qLSku5Qe_QFe_wgT1UGu0w9tyOnZnaQ5pTJnJ0UlMzW_hsrL4To3esDWZ_uBw5MDh8yM-G3sYJuSWXx4_x_s239nLz4fstWetTGkFLH91Q5KzG4Yfj6I2Q2DmYYhuz242srfTtPv598BCEMDLQ</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Bergmann, Sven</creator><creator>Sandler, Oded</creator><creator>Sberro, Hila</creator><creator>Shnider, Sara</creator><creator>Schejter, Eyal</creator><creator>Shilo, Ben-Zion</creator><creator>Barkai, Naama</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>CZG</scope></search><sort><creationdate>20070201</creationdate><title>Pre-steady-state decoding of the Bicoid morphogen gradient</title><author>Bergmann, Sven ; Sandler, Oded ; Sberro, Hila ; Shnider, Sara ; Schejter, Eyal ; Shilo, Ben-Zion ; Barkai, Naama</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c823t-a0a8aeb70bfec1748f35389cf8aa112c9744b625473a5cdea0a3e26cbd968ea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Body Patterning - 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It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may precede the convergence of the gradient to its steady state. Here we consider the implications of pre-steady-state decoding of the Bicoid morphogen gradient for patterning of the anterior-posterior axis of the Drosophila embryo. Quantitative analysis of the shift in the expression domains of several Bicoid targets (gap genes) upon alteration of bcd dosage, as well as a temporal analysis of a reporter for Bicoid activity, suggest that a transient decoding mechanism is employed in this setting. We show that decoding the pre-steady-state morphogen profile can reduce patterning errors caused by fluctuations in the rate of morphogen production. This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>17298180</pmid><doi>10.1371/journal.pbio.0050046</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Body Patterning - physiology Cell Differentiation - genetics Computational Biology Developmental Biology Drosophila Drosophila - embryology Drosophila - genetics Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Drosophila Proteins - physiology Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Embryonic Development Embryos Gene expression Gene Expression Regulation, Developmental Genes, Reporter Genetic aspects Genetics and Genomics GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Homeodomain Proteins - metabolism Homeodomain Proteins - physiology Insects Morphogenesis Observations Signal Transduction Studies Trans-Activators - metabolism Trans-Activators - physiology |
| title | Pre-steady-state decoding of the Bicoid morphogen gradient |
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